The sympathetic nervous system in hypertension: a potential long-term regulator of arterial pressure.
The sympathetic nervous system in hypertension: a potential long-term regulator of arterial pressure.
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发表时间：
1996-12
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通讯作者：
A. Mark
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作者：
A. Mark
高血压时交感神经活动的未标记增加：最近，两种技术（交感神经活动神经内记录的显微神经摄影方法和去甲肾上腺素动力学研究的放射性示踪技术）已被用于获得人类区域交感神经功能的复杂见解。现在有说服力的证据表明，年轻的轻度高血压患者交感神经活动增加。动脉压的长期调节：已经提出了三种可靠的机制来维持高血压的长期交感神经影响：肾交感神经的抗心房利尿和肾素刺激作用，交感神经对血管膜特性发育的影响以及交感神经对血管和心肌的营养作用。结论越来越多的证据表明交感神经系统在原发性高血压的发病机制和动脉血压的长期调节中起主要作用。
UNLABELLED INCREASED SYMPATHETIC NERVE ACTIVITY IN HYPERTENSION: Two techniques (the microneurographic method for intraneural recordings of sympathetic nerve activity and radiotracer techniques for study of norepinephrine kinetics) have been used recently to obtain sophisticated insight into regional sympathetic function in humans. Persuasive evidence now indicates that young mildly hypertensive humans have increased sympathetic neural activity. LONG-TERM REGULATION OF ARTERIAL PRESSURE: Three credible mechanisms have been proposed to sustain long-term sympathetic nervous influences in hypertension: antinatriuretic and renin stimulating effects of the renal sympathetic nerves, sympathetic influences on the development of vascular membrane properties and trophic effects of the sympathetic nerves on vascular and cardiac muscle. CONCLUSION There is increasing evidence that the sympathetic nervous system may play a primary role in the pathogenesis of essential hypertension and the long-term regulation of arterial pressure.