Plasma levels of t-PA and PAI-1 correlate with the formation of experimental post-surgical peritoneal adhesions.
Plasma levels of t-PA and PAI-1 correlate with the formation of experimental post-surgical peritoneal adhesions.
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DOI：
10.1155/mi/2006/13901
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发表时间：
2006
影响因子：
4.6
通讯作者：
Cennamo A
中科院分区：
文献类型：
--
作者：
Di Filippo C;Falsetto A;De Pascale V;Tufariello E;De Lucia D;Rossi F;D'Amico M;Cennamo A
本研究评价了纤溶酶原激活物（t-PA）和纤溶酶原激活物抑制剂-1（派-1）的全身变化是否与粘连的发展平行，以及它们是否可用作粘连风险的预测因子。这已经在手术后腹膜粘连的动物模型中通过监测t-PA和派-1的血浆和组织水平10天进行了研究。结果表明，组织和血浆t-PA水平均随腹膜粘连的发展而下降。相比之下，在5天和10天时间点采集的大鼠的组织和血浆样品中发现派-1增加。腹腔灌洗液中的炎性介质如ICAM-1、VCAM-1和IL-6也与粘连形成过程相关。总之，手术后腹膜粘连导致局部炎症成分以及局部和全身纤溶成分的改变，可能与派-1淬灭t-PA有关。这可能具有识别高风险患者的潜力。
This study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adhesion by monitoring for 10 days the plasma and tissue levels of t-PA and PAI-1. The results showed that both tissular and plasmatic levels of t-PA were decreased in concomitance with the development of peritoneal adhesions. In contrast, PAI-1 was found increased into the tissue and into the plasma samples of the rats taken at 5 and 10 days time points. Inflammatory mediators such as ICAM-1, VCAM-1, and IL-6 within the peritoneal lavage fluid also correlated with the adhesion formation process. In conclusion, post-surgical peritoneal adhesions provide alterations of local inflammatory components and local and systemic fibrinolytic components, possibly with PAI-1 quenching t-PA. This may have potential for the identification of high-risk patients.