Event-related potentials in an auditory oddball situation in the rat
Event-related potentials in an auditory oddball situation in the rat
复制标题
DOI：
10.1016/j.biosystems.2004.09.017
复制
发表时间：
2005-01-01
期刊：
影响因子：
1.6
通讯作者：
Villa, AEP
中科院分区：
文献类型：
--
作者：
Eriksson, J;Villa, AEP
诱发电位记录从听觉皮层的自由移动和麻醉大鼠时，异常的声音在一系列的标准声音（oddball条件）的同质。对异常声音的诱发反应的一个组成部分，失配负性（MMN），可能是区分声学差异的能力的基础，这是听觉感知的一个基本方面。虽然大多数动物MMN研究都是使用简单的声音进行的，但这项研究涉及一组更复杂的声音（合成元音）。这些自由活动的老鼠之前接受过行为训练，在训练中它们学会了对这些声音做出不同的反应。虽然我们发现很少的证据，在这种准备的典型的，神经记录，MMN的反应，一个显着的差异，偏差和标准诱发电位之间的自由移动的动物在100-200毫秒范围内刺激开始。在麻醉动物中未发现此类差异。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Evoked potentials were recorded from the auditory cortex of both freely moving and anesthetized rats when deviant sounds were presented in a homogenous series of standard sounds (oddball condition). A component of the evoked response to deviant sounds, the mismatch negativity (MMN), may underlie the ability to discriminate acoustic differences, a fundamental aspect of auditory perception. Whereas most MMN studies in animals have been done using simple sounds, this study involved a more complex set of sounds (synthesized vowels). The freely moving rats had previously undergone behavioral training in which they learned to respond differentially to these sounds. Although we found little evidence in this preparation for the typical, epidurally recorded, MMN response, a significant difference between deviant and standard evoked potentials was noted for the freely moving animals in the 100-200 ms range following stimulus onset. No such difference was found in the anesthetized animals. (C) 2004 Elsevier Ireland Ltd. All rights reserved.