Renormalized basal metabolic rate describes the human aging process and longevity
Renormalized basal metabolic rate describes the human aging process and longevity
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DOI：
10.1111/acel.12968
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发表时间：
2019-08-01
期刊：
影响因子：
7.8
通讯作者：
Tanaka, Masashi
中科院分区：
文献类型：
--
作者：
Kitazoe, Yasuhiro;Kishino, Hirohisa;Tanaka, Masashi
我们为什么会变老并最终死亡，这个问题一直是生命科学、医学和健康科学的中心课题。许多衰老理论都提出了与衰老相关的生物标志物。然而，它们还没有足够的能力来预测老化过程和寿命。我们在此提出了一种基于质量特异性基础代谢率（msBMR）的人类衰老新生物标志物。哈里斯-本尼迪克特方程表明，msBMR随着年龄的增长而下降，但个体之间存在差异。我们试图通过将身体质量指数纳入这个方程来重新规范msBMR。从一个美国男性队列（n = 25,425）中得出的重整化msBMR （RmsBMR）被认为是最好的衰老生物标志物之一，因为它可以很好地再现分别观察到的美国、意大利和日本的死亡率和生存曲线数据。最近观察到的百岁老人死亡率平稳期与代表人类生命最后阶段的RmsBMR的最低值（阈值）相对应。随着年龄的增长，RmsBMR的普遍下降与线粒体数量的衰减有关，这是由动态聚变/裂变系统的轻微波动引起的。通过对小鼠的测量，观察到这种衰变形式。最后，本方法解释了哺乳动物BMR受经验算术标度律调节的原因。
The question of why we age and finally die has been a central subject in the life, medical, and health sciences. Many aging theories have proposed biomarkers that are related to aging. However, they do not have sufficient power to predict the aging process and longevity. We here propose a new biomarker of human aging based on the mass-specific basal metabolic rate (msBMR). It is well known by the Harris-Benedict equation that the msBMR declines with age but varies among individual persons. We tried to renormalize the msBMR by primarily incorporating the body mass index into this equation. The renormalized msBMR (RmsBMR) which was derived in one cohort of American men (n = 25,425) was identified as one of the best biomarkers of aging, because it could well reproduce the observed respective American, Italian, and Japanese data on the mortality rate and survival curve. A recently observed plateau of the mortality rate in centenarians corresponded to the lowest value (threshold) of the RmsBMR, which stands for the final stage of human life. A universal decline of the RmsBMR with age was associated with the mitochondrial number decay, which was caused by a slight fluctuation of the dynamic fusion/fission system. This decay form was observed by the measurement in mice. Finally, the present approach explained the reason why the BMR in mammals is regulated by the empirical algometric scaling law.