Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study
Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study
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DOI：
10.1016/j.nicl.2019.101781
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Ojeda, Natalia
中科院分区：
文献类型：
--
作者：
Gomez-Gastiasoro, Ainara;Zubiaurre-Elorza, Leire;Ojeda, Natalia
背景：白质（WM）的改变在精神分裂症中有很好的记录。半球间纤维的异常似乎解释了该疾病中WM不对称性的改变。然而，这些改变的区域特异性（例如，额部与枕部）及其对精神分裂症认知功能障碍的潜在贡献仍然未知。方法：41例精神分裂症患者和21例健康对照（HC）在3特斯拉MRI机上进行弥散加权成像。采用基于神经束的空间统计（FSL）方法评估WM全脑差异。为了分别测量额部和枕部脑脊髓束，进行了概率脑脊髓束造影。参与者还完成了语言记忆和处理速度的测试。重复测量分析进行协方差分析和Pearson相关分析。结果：分数各向异性（FA）存在显著的组x大脑半球相互作用(F-(1,F-17) = 7.03；P = 0.017；eta（2)(p)= 0.29）和径向扩散系数（RD） (F-(1,F-17) = 4.84；P = 0.042；与HC相比，患者额道的eta(2)(p)= 0.22。与表现相反模式的患者相比，健康对照组在左额束显示较高的平均FA和较低的平均RD。在精神分裂症患者中，右额叶平均FA和RD与言语记忆相关（r = -0.68, p = 0.046; r = 0.77, p = 0.015）。结论：在精神分裂症患者的额道中发现了不对称的WM改变。较高的右额叶平均FA与较差的言语记忆表现相关，表明这些大脑变化可能导致精神分裂症患者的认知障碍。
Background: White matter (WM) alterations are well documented in schizophrenia. Abnormalities in interhemispheric fibers appear to account for altered WM asymmetry in the illness. However, the regional specificity (e.g., frontal versus occipital) of these alterations and their potential contribution to cognitive dysfunction in schizophrenia remain unknown.Methods: Forty one patients with schizophrenia and 21 healthy controls (HC) underwent diffusion-weighted imaging on a 3 Tesla MRI machine. Tract-based spatial statistic (FSL) was used to assess whole brain differences in WM. Probabilistic tractography was performed in order to separately measure frontal and occipital WM tracts. Participants also completed tests of verbal memory and processing speed. Repeated measures analyses of covariance and Pearson correlation analyses were performed.Results: A significant group x cerebral hemisphere interaction was found for fractional anisotropy (FA) (F-(1,F-17) = 7.03; p = .017; eta(2 )(p)= 0.29) and radial diffusivity (RD) (F-(1,F-17) = 4.84; p = .042; eta(2 )(p)= 0.22) in the frontal tract of patients versus HC. Healthy controls showed higher mean FA and lower mean RD in the left frontal tract compared to patients, who showed the opposite pattern. In patients with schizophrenia, mean FA and RD in the right frontal tract correlated with verbal memory (r = -0.68, p = .046; r = 0.77, p = .015).Conclusions: Asymmetric WM alterations were found in a frontal tract of patients with schizophrenia. Higher mean FA in the right frontal tract correlated with worse verbal memory performance, suggesting a possible contribution these brain changes to cognitive impairment in schizophrenia.