Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.
Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.
复制标题
居住在社区和疗养院的患者阿托伐他汀清除率的人群分析。
DOI：
10.1038/clpt.2009.100
复制
发表时间：
2009
影响因子：
6.7
通讯作者：
Verotta,D
中科院分区：
文献类型：
--
作者：
Schwartz,JB;Verotta,D
The effects of demographic and clinical covariates on the apparent clearance (CL/F) of orally administered atorvastatin, with chronic dosing in a patient population that included the elderly, were studied in 143 patients (atorvastatin: 34 ± 26 mg/day, mean ± SD; men (n= 64), age 64.6 ± 12.1 years, and women (n= 79), age 69.3 ± 13 years). The time of dose administration had a strong influence on Ka (faster with morning dosing); the factors found to slow CL/F were coadministration of CYP3A inhibitors and advancing age—the latter factor was relevant only in the men, not in the women.Clinical Pharmacology & Therapeutics(2009)865, 497–502. doi:10.1038/clpt.2009.100
