Highly efficient, general procedure for the preparation of alkylzinc reagents from unactivated alkyl bromides and chlorides
Highly efficient, general procedure for the preparation of alkylzinc reagents from unactivated alkyl bromides and chlorides
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DOI：
10.1021/ol0272693
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发表时间：
2003-02-20
期刊：
影响因子：
5.2
通讯作者：
Huo, SQ
中科院分区：
文献类型：
--
作者：
Huo, SQ
在极性非质子溶剂中，将1-5 mol % I-2活化的金属锌（粉尘、粉末、颗粒、弹丸）直接插入烷基溴化物中，有效地制备了烷基溴化锌。由此形成的锌试剂经过Ni和pd催化与芳基卤化物的交叉偶联，以优异的收率生产功能化烷基烯。
[GRAPHICS]Alkylzinc bromides have been efficiently prepared by the direct insertion of zinc metal (dust, powder, granule, shot), activated with 1-5 mol % I-2, into alkyl bromides in a polar aprotic solvent. The zinc reagents thus formed undergo Ni- and Pd-catalyzed cross-coupling with aryl halides to produce functionalized alkylarenes in excellent yields.