PRODUCTION OF IMMUNOGLOBULIN ISOTYPES BY LY-1+ B-CELLS IN VIABLE MOTH-EATEN AND NORMAL MICE
PRODUCTION OF IMMUNOGLOBULIN ISOTYPES BY LY-1+ B-CELLS IN VIABLE MOTH-EATEN AND NORMAL MICE
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DOI：
10.1126/science.3487115
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发表时间：
1986-06-13
期刊：
影响因子：
56.9
通讯作者：
HERZENBERG, LA
中科院分区：
文献类型：
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作者：
SIDMAN, CL;SHULTZ, LD;HERZENBERG, LA
几乎所有的B细胞在自身免疫小鼠与可行的motheasten（mev）突变表达Ly-1细胞表面抗原，这标志着一个小群体的B细胞构成一个单独的谱系在正常小鼠。主要是M和G3类的免疫球蛋白，其在正常和mev小鼠中都含有高水平的λ轻链，在mev小鼠中过量产生。这些和其他观察结果表明，表达Ly-1的B细胞的发育与不表达Ly-1的B细胞的发育无关。携带Ly-1表面抗原的B细胞可以通过淋巴因子调节其它B细胞、通过产生针对自身和某些外来抗原的抗体以及通过优先分泌免疫球蛋白M和免疫球蛋白G3而在正常免疫系统和自身免疫中发挥特殊作用。
Almost all B cells in autoimmune mice with the viable motheasten (mev) mutation express the Ly-1 cell surface antigen, which marks a minor population of B cells constituting a separate lineage in normal mice. Immunoglobulins primarily of the M and G3 classes, which in both normal and mev mice contain high levels of lambda light chain, are produced in excess in mev mice. These and other observations suggest that the development of B cells that express Ly-1 is regulated independently from the development of B cells that do not express Ly-1. B cells bearing the Ly-1 surface antigen may play specialized roles in the normal immune system and in autoimmunity by regulating other B cells via lymphokines, by producing antibodies to self and certain foreign antigens, and by preferentially secreting immunoglobulin M and immunoglobulin G3.