Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells.
Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells.
复制标题
多发性骨髓瘤骨髓间充质基质细胞早期衰老的证据。
DOI：
10.1371/journal.pone.0059756
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lagneaux L
中科院分区：
文献类型：
--
作者：
André T;Meuleman N;Stamatopoulos B;De Bruyn C;Pieters K;Bron D;Lagneaux L
在多发性骨髓瘤中，骨髓间充质基质细胞支持骨髓瘤细胞生长。以往的研究表明，恶性肿瘤细胞与骨髓间充质基质细胞之间的直接和间接相互作用导致骨髓间充质基质细胞的组成异常。本研究的目的是研究骨髓瘤骨髓间充质基质细胞的组成异常，并评估新的治疗方法的影响。我们证明，骨髓瘤骨髓间充质基质细胞具有衰老相关β-半乳糖苷酶表达增加、细胞大小增加、增殖能力降低和衰老相关分泌谱成员的特征性表达。我们还观察到成骨细胞生成能力和免疫调节活性降低，造血支持能力增加。最后，我们确定，目前的治疗能够部分减少分泌因子，增殖和成骨细胞生成的一些异常。我们发现，骨髓瘤骨髓间充质基质细胞有一个早期衰老的轮廓，其特征发生了深刻的变化。这种衰老状态很可能通过改变肿瘤微环境参与疾病进展和复发。
In multiple myeloma, bone marrow mesenchymal stromal cells support myeloma cell growth. Previous studies have suggested that direct and indirect interactions between malignant cells and bone marrow mesenchymal stromal cells result in constitutive abnormalities in the bone marrow mesenchymal stromal cells. The aims of this study were to investigate the constitutive abnormalities in myeloma bone marrow mesenchymal stromal cells and to evaluate the impact of new treatments. We demonstrated that myeloma bone marrow mesenchymal stromal cells have an increased expression of senescence-associated β-galactosidase, increased cell size, reduced proliferation capacity and characteristic expression of senescence-associated secretory profile members. We also observed a reduction in osteoblastogenic capacity and immunomodulatory activity and an increase in hematopoietic support capacity. Finally, we determined that current treatments were able to partially reduce some abnormalities in secreted factors, proliferation and osteoblastogenesis. We showed that myeloma bone marrow mesenchymal stromal cells have an early senescent profile with profound alterations in their characteristics. This senescent state most likely participates in disease progression and relapse by altering the tumor microenvironment.
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影响因子：
3.7
作者：
Coppé JP;Patil CK;Rodier F;Krtolica A;Beauséjour CM;Parrinello S;Hodgson JG;Chin K;Desprez PY;Campisi J
通讯作者：
Campisi J
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
20.3
作者：
Davies, FE;Dring, AM;Anderson, KC
通讯作者：
Anderson, KC
影响因子：
4
作者：
Feng, Yongdong;Wen, Jianguo;Chang, Chung-Che
通讯作者：
Chang, Chung-Che
影响因子：
11.4
作者：
Corre, J.;Mahtouk, K.;Bourin, P.
通讯作者：
Bourin, P.