STIMULATION OF IRRITANT RECEPTORS AND AFFERENT C-FIBERS IN LUNGS BY PROSTAGLANDINS
STIMULATION OF IRRITANT RECEPTORS AND AFFERENT C-FIBERS IN LUNGS BY PROSTAGLANDINS
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DOI：
10.1038/264451a0
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发表时间：
1976-01-01
期刊：
影响因子：
64.8
通讯作者：
MORRISON, MA
中科院分区：
文献类型：
--
作者：
COLERIDGE, HM;COLERIDGE, JCG;MORRISON, MA
肺是产生、释放和破坏前列腺素（PGs）的众多器官之一。有人认为，PC作为"局部酶" 2，使许多物种的支气管和肺血管平滑肌松弛的E1和E2，以及使其收缩的F2 α，可能与气道和肺血管口径的正常调节有关3。PGF 2 α被认为是哮喘的致病因素4。PGF 2 α的支气管收缩作用会被阿托品减弱，因此可能涉及反射成分5。在PGE1和PGE2作为支气管扩张剂治疗哮喘的临床试验中报告了咳嗽和气道刺激6，7。因此，前列腺素可能会刺激肺部的传入神经末梢，并且已经有人猜测涉及哪些末梢。我们记录了麻醉犬肺部快速适应性肺牵张（刺激性）受体8，9和传入C纤维末梢10，11的冲动活动。当将PGF 2 α注入右心房时，肺“刺激性”受体被强烈刺激。相比之下，注射前列腺素E引起肺C纤维的显著和长期刺激。
THE lungs are among the many organs that generate, release and destroy prostaglandins (PGs)1. It has been suggested that PCs act as ‘local hormones’2, so that prostaglandins E1and E2, which relax the smooth muscle of bronchi and pulmonary blood vessels in many species, and F2α, which contracts it, may be implicated in normal regulation of airway and pulmonary vascular calibre3. PGF2αhas been proposed as a causal factor in asthma4. The bronchoconstrictor effect of PGF2αis reduced by atropine, hence a reflex component may be involved5. Cough and airway irritation have been reported in clinical trials of PGE1and PGE2as bronchodilators in the treatment of asthma6,7. Thus PGs may stimulate afferent nerve endings in the lungs, and there has been speculation as to which endings are involved. We have recorded impulse activity from rapidly-adapting pulmonary stretch (’irritant‘) receptors8,9and afferent C-fibre endings10,11in the lungs of anaesthetised dogs. When PGF2αwas injected into the right atrium, lung ‘irritant’ receptors were strongly stimulated. Injection of PGEs, by contrast, caused marked and prolonged stimulation of lung C-fibres.