Forever young: Mechanisms of natural anoxia tolerance and potential links to longevity
Forever young: Mechanisms of natural anoxia tolerance and potential links to longevity
复制标题
永远年轻：自然耐缺氧的机制和与长寿的潜在联系
DOI：
10.4161/oxim.3.3.4
复制
发表时间：
2010
影响因子：
--
通讯作者：
K. Storey
中科院分区：
文献类型：
--
作者：
A. Krivoruchko;K. Storey
虽然哺乳动物不能在缺氧状态下存活超过几分钟而不遭受严重的器官损伤，但一些动物已经掌握了无氧生活。淡水龟属于Trachemys属和Ammeremys属，是脊椎动物世界的兼性厌氧菌冠军，经常在没有氧气的情况下存活数周。龟类耐缺氧的生理生化机制包括代谢率降低、蛋白质翻译后修饰、抗氧化防御、特异性应激应答转录因子的激活以及细胞保护蛋白的表达增强。海龟也以其令人难以置信的长寿而闻名，并显示出“可忽略的衰老”的特征。我们认为，强大的压力耐受机制，允许长期厌氧的海龟也可能支持这些动物的寿命。许多参与天然缺氧耐受的机制，如代谢减退或诱导各种保护性蛋白/途径，已被证明在哺乳动物氧相关疾病中起重要作用，并且对细胞如何在没有氧气的情况下存活的理解的提高可以帮助理解和治疗涉及缺氧或氧化应激的各种病理状况。在本综述中，我们讨论了最近取得的进展，了解缺氧耐受性的分子性质的海龟和这种耐受性和寿命之间的潜在联系。
While mammals cannot survive oxygen deprivation for more than a few minutes without sustaining severe organ damage, some animals have mastered anaerobic life. Freshwater turtles belonging to the Trachemys and Chrysemys genera are the champion facultative anaerobes of the vertebrate world, often surviving without oxygen for many weeks at a time. The physiological and biochemical mechanisms that underlie anoxia tolerance in turtles include profound metabolic rate depression, post-translational modification of proteins, strong antioxidant defenses, activation of specific stress-responsive transcription factors, and enhanced expression of cyto-protective proteins. Turtles are also known for their incredible longevity and display characteristics of “negligible senescence.” We propose that the robust stress-tolerance mechanisms that permit long term anaerobiosis by turtles may also support the longevity of these animals. Many of the mechanisms involved in natural anoxia tolerance, such as hypometabolism or the induction of various protective proteins/pathways, have been shown to play important roles in mammalian oxygen-related diseases and improved understanding of how cells survive without oxygen could aid in the understanding and treatment of various pathological conditions that involve hypoxia or oxidative stress. In the present review we discuss the recent advances made in understanding the molecular nature of anoxia tolerance in turtles and the potential links between this tolerance and longevity.
登录
查看更多内容
DOI：
10.1152/ajpheart.1996.270.1.h107
发表时间：
1996-01-01
影响因子：
4.8
作者：
Motterlini, R;Foresti, R;Winslow, RM
通讯作者：
Winslow, RM
DOI：
--
发表时间：
1987-06
期刊：
The British journal of cancer. Supplement
影响因子：
--
作者：
N. Oleinick;S. Chiu;Narayani Ramakrishnan;L. Xue
通讯作者：
N. Oleinick;S. Chiu;Narayani Ramakrishnan;L. Xue
DOI：
10.1016/0305-0491(95)02043-8
发表时间：
1996
期刊：
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
影响因子：
--
作者：
Kenneth B. Storey
通讯作者：
Kenneth B. Storey
DOI：
10.1152/ajpregu.1996.271.3.r545
发表时间：
1996-09-01
影响因子：
2.8
作者：
Joanisse, DR;Storey, KB
通讯作者：
Storey, KB
DOI：
10.1152/ajplung.00278.2004
发表时间：
2005-03-01
影响因子：
4.9
作者：
Buckley, S;Barsky, L;Warburton, D
通讯作者：
Warburton, D