In search of treatment for tardive dyskinesia: review of the literature.
In search of treatment for tardive dyskinesia: review of the literature.
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寻找迟发性运动障碍的治疗方法：文献综述。
DOI：
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发表时间：
1979
影响因子：
6.6
通讯作者：
Richard Jed Wyatt
中科院分区：
文献类型：
--
作者：
Dilip V. Jeste;Richard Jed Wyatt
对截至 1978 年 8 月为止在英文文献中发表的关于抗精神病药引起的迟发性运动障碍治疗的研究进行了回顾。目前还没有一种令人满意的治疗迟发性运动障碍的方法。年轻和非脑损伤患者停用抗精神病药可以缓解症状。矛盾的是，抑制运动障碍最有效的治疗方法是服用抗精神病药。运动障碍患者继续使用精神安定药会产生不可逆的脑损伤的可能性仍有待验证（或无效）。抗胆碱能药物和多巴胺能药物对于迟发性运动障碍的治疗没有价值。在这种情况下，胆碱能药物并没有达到最初的预期效果。大约三分之一的运动障碍受试者似乎对各种非特异性措施有反应。迟发性运动障碍可能至少包含两种亚型——可逆性和持续性。讨论了早期研究的方法论方面以及该领域未来研究的可能性。还概述了个别病例的治疗建议。
Studies on the treatments for neuroleptic-induced tardive dyskinesia published in the English literature until August 1978 are reviewed. There is a yet no single satisfactory method of treatment for tardive dyskinesia. Withdrawal of neuroleptics results in a remission of symptoms in younger and non-brain-damaged patients. Paradoxically, the most effective treatment for suppressing dyskinesia is administration of neuroleptics. The possibility that continued use of neuroleptics in dyskinesia patients produces irreversible brain damage remains to be validated (or invalidated). Anticholinergic and dopaminergic drugs are of no value in the treatment of tardive dyskinesia. Cholinergic drugs have not lived up to their initial promising results in this condition. About one third of the dyskinetic subjects seem to respond to various nonspecific measures. Tardive dyskinesia probably consists of at least two subtypes-- reversible and persistent. Methodological aspects of earlier studies and possibilities for future research in this field are discussed. Suggestions for treatment of individual cases are also outlined.