Effects of short-term prednisolone intake during submaximal exercise
Effects of short-term prednisolone intake during submaximal exercise
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DOI：
10.1249/mss.0b013e3180dc992c
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发表时间：
2007-09-01
期刊：
影响因子：
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通讯作者：
Collomp, Katia
中科院分区：
文献类型：
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作者：
Arlettaz, Alexandre;Portier, Hugues;Collomp, Katia
目的：探讨泼尼松龙在亚极量运动中的增能和代谢作用。研究方法：根据双盲和随机方案，10名娱乐性男性运动员在70-75%峰值O-2消耗量下完成了两项自行车试验，直至在安慰剂（Pla，乳糖）或口服泼尼松龙（Pred，60 mg.d（-1），1 wk）治疗后耗尽。在休息和运动及恢复期间采集血样，以测定ACTH、生长激素（GH）、催乳素（PRL）、脱氢表雄酮（DHEA）、胰岛素、血糖和血乳酸值。结果：慢性Pred治疗后骑自行车时间明显延长（Pred：74.5 ± 9.5min; Pla：46.1 ± 3.3min，P <0.01）。Pred摄入量显着降低基础，运动和恢复ACTH，DHEA和PRL浓度，而GH浓度显着降低Pred运动30分钟后。在整个实验过程中，直到运动30 min，Pred均显著升高血糖和胰岛素（P < 0.05）。运动后10 min至恢复后10 min，Pred组血乳酸浓度高于Pla组（P < 0.05）。结论：从这些数据来看，短期摄入Pred似乎确实显著改善了次极量运动期间的表现，同时伴随着激素和代谢反应的改变。进一步的研究将是必要的，以阐明这些激素和代谢变化的机制，并确定这些变化是否可能与所获得的显着性能改善。
Purpose: To examine the prednisolone's ergogenic and metabolic effects during submaximal exercise. Methods: Ten recreational male athletes completed two cycling trials at 70-75% peak O-2 consumption until exhaustion after either placebo (Pla, lactose) or oral prednisolone (Pred, 60 mg.d(-1) for 1 wk) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest and during exercise and recovery to determine ACTH, growth hormone (GH), prolactin (PRL), DHEA, insulin, blood glucose, and blood lactate values. Results: Time of cycling was significantly increased after chronic Pred treatment (Pred: 74.5 +/- 9.5 min; Pla: 46.1 +/- 3.3 min, P < 0.0 1). Pred intake significantly lowered basal, exercise, and recovery ACTH, DHEA, and PRL concentrations, whereas GH concentrations were significantly lowered by Pred after 30 min of exercise. Blood glucose and insulin were significantly (P < 0.05) increased by Pred during the whole experiment and until 30 min of exercise. Blood lactate concentrations were higher after Pred versus Pla at 10 min of exercise until 10 min of recovery (P < 0.05). Conclusion: From these data, short-term Pred intake did seem to significantly improve performance during submaximal exercise, with concomitant alterations in hormonal and metabolic responses. Further studies will be necessary to elucidate the mechanisms of these hormonal and metabolic changes, and to determine whether the changes may be associated with the marked performance improvement obtained.