Drug-induced hypergastrinemia: absence of trophic effects on colonic carcinoma in rats.
Drug-induced hypergastrinemia: absence of trophic effects on colonic carcinoma in rats.
复制标题
药物引起的高胃泌素血症：对大鼠结肠癌缺乏营养作用。
DOI：
10.1016/0016-5085(95)90204-x
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发表时间：
1995
期刊：
影响因子：
29.4
通讯作者：
Hurwitz,A
中科院分区：
文献类型：
--
作者：
Pinson,DM;Havu,N;Sztern,MI;Mattsson,H;Looney,GA;Kimler,BF;Hurwitz,A
背景/目的已发表的研究表明，高胃泌素血症刺激正常或恶性结肠组织的生长。其他研究对这些发现提出了质疑。这项研究的目的是测试的假设，高胃泌素血症增强结肠癌的进展或invasiveness of colon cancer.MethodsColonic癌在雄性Sprague-Dawley大鼠诱导每周6次腹腔注射methylazoxymethanol。最后一次注射致癌物后四周，将动物随机分为四个治疗组，包括溶剂对照组、低剂量和高剂量奥美拉唑组和雷尼替丁组。治疗10周后，对动物流血的，记录胃重量，并通过Dukes分类对结肠肿瘤进行定位、计数、测量和组织病理学评分。隐窝和粘膜高度在结肠粘膜不受tumor.ResultsDrug administration诱导持续高胃泌素血症，并没有提高肿瘤负荷或侵袭性或隐窝高度/粘膜高度比确定。雷尼替丁治疗的大鼠消耗更少的食物，体重更轻，肿瘤也更少。该组也有较低的隐窝和粘膜高度比大鼠在vehicleor omeprazole-treated rats.ConclusionsThe结果表明，内源性高胃泌素血症诱导这些抑酸药物对结肠粘膜的生长或进展或实验大鼠结肠癌的生物学行为没有刺激作用。
Background/AimsPublished studies suggest that hypergastrinemia stimulates growth of normal or malignant colon tissue. Other studies dispute these findings. This study was designed to test the hypothesis that hypergastrinemia enhances progression or invasiveness of colon cancer.MethodsColonic carcinomas were induced in male Sprague-Dawley rats by six weekly intraperitoneal injections of methylazoxymethanol. Four weeks after the last injection of carcinogen, the animals were randomized into four treatment groups, including vehicle control, low- and high-dose omeprazole, and ranitidine. After 10 weeks of treatment, the animals were bled, stomach weights were recorded, and colon tumors were mapped, enumerated, measured, and scored histopathologically by Dukes' classification. Crypt and mucosal heights were determined in colonic mucosa unaffected by tumor.ResultsDrug administration induced a sustained hypergastrinemia that did not enhance tumor burden or invasiveness or crypt height/mucosal height ratios. Ranitidine-treated rats consumed less food, weighed less, and developed fewer tumors. This group also had lower crypt and mucosal heights than rats in the vehicleor omeprazole-treated rats.ConclusionsThe results suggest that endogenous hypergastrinemia induced by these acid-suppressing drugs has no stimulatory effect on colon mucosal growth or progression or biological behavior of experimental rat colon cancer.