Single cell pattern formation and transient cytoskeletal arrays.

Single cell pattern formation and transient cytoskeletal arrays.
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DOI:
10.1016/j.ceb.2013.09.005
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发表时间:
2014-02
影响因子:
7.5
通讯作者:
von Dassow, George
von Dassow, George
中科院分区:
生物学2区
文献类型:
--
作者:
Bement, William M.;von Dassow, George

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发育生物学的一个主要目标是解释细胞层、组织和器官中模式的出现。发育生物学家现在承认,基于反应扩散的机制广泛应用于发育中的生物体以指导模式形成。在这里,我们简要考虑这些机制,然后将源自它们的一些概念应用于单细胞中发生的几个过程:伤口修复、酵母出芽和胞质分裂。该分析得出两个结论:首先,发育和单细胞模式形成之间的一般机制水平存在相当大的重叠;其次,基于肌动蛋白细胞骨架的动态结构可能比通常认为的更加有序。
A major goal of developmental biology is to explain the emergence of pattern in cell layers, tissues and organs. Developmental biologists now accept that reaction diffusion-based mechanisms are broadly employed in developing organisms to direct pattern formation. Here we briefly consider these mechanisms and then apply some of the concepts derived from them to several processes that occur in single cells: wound repair, yeast budding, and cytokinesis. Two conclusions emerge from this analysis: first, there is considerable overlap at the level of general mechanisms between developmental and single cell pattern formation; second, dynamic structures based on the actin cytoskeleton may be far more ordered than is generally recognized.
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