C3-Symmetric Chiral Trisimidazoline: Design and Application to Organocatalyst
C3-Symmetric Chiral Trisimidazoline: Design and Application to Organocatalyst
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DOI：
10.1021/ol902958m
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发表时间：
2010-03-05
期刊：
影响因子：
5.2
通讯作者：
Fujioka, Hiromichi
中科院分区：
文献类型：
--
作者：
Murai, Kenichi;Fukushima, Shunsuke;Fujioka, Hiromichi
以3个C2对称手性组分构建C3对称分子的概念，设计合成了一种新型的C3对称手性三咪唑啉催化剂，并将其应用于β-酮酯与硝基烯烃的不对称共轭加成反应。
C-3-symmetric chiral trisimidazoline was designed and synthesized as a new entry of organocatalyst with the concept of constructing C-3-symmetric molecules with three C-2-symmetric chiral components, and the application of this novel catalyst to asymmetric conjugate addition of beta-ketoesters to nitroolefins was described.