Endocytosis and exocytosis of nanoparticles in mammalian cells.
Endocytosis and exocytosis of nanoparticles in mammalian cells.
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DOI：
10.2147/ijn.s26592
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发表时间：
2014
影响因子：
8
通讯作者：
Park JH
中科院分区：
文献类型：
--
作者：
Oh N;Park JH
可以注射到人体内的工程纳米粒子在检测和治疗复杂疾病方面具有巨大的潜力。了解纳米颗粒的内吞和胞吐机制对于安全和有效的治疗应用是必不可少的。特别地，胞吐作用在从体内去除具有药物和造影剂的纳米颗粒方面具有重要意义，而胞吞作用对于将纳米颗粒靶向疾病部位非常重要。在这里，我们回顾了最近的研究功能化纳米粒子的内吞和胞吐的基础上，不同的尺寸，形状和表面化学。我们相信，这一审查有助于设计安全的纳米粒子，可以有效地进入和离开人体细胞和组织。
Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues.