l-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects.
l-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects.
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DOI：
10.1016/j.pathophys.2015.05.001
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发表时间：
2015-09-01
期刊：
影响因子：
--
通讯作者：
Jaja, S I
中科院分区：
文献类型：
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作者：
Kehinde, M O;Ogungbemi, S I;Jaja, S I
在镰状细胞病患者中研究了口服低剂量l-精氨酸补充剂（1g/天，持续6周）对抗氧化活性、血液学参数和红细胞渗透脆性的影响。本研究招募了28名镰状细胞贫血受试者。从肘前静脉抽取5毫升血液，用于估计受试者的血浆精氨酸浓度（[R]）、总抗氧化酶（TAE）活性、丙二醛浓度（[MDA]）、RBC计数、[Hb]、PCV、MCHC、MCV、MCH、不可逆镰状细胞百分比（%ISC）和红细胞渗透脆性。L-精氨酸补充增加[R]（p
The effect of oral, low-dose l-arginine supplementation (1g/day for 6 weeks) on antioxidant activity, haematological parameters and osmotic fragility of red blood cells was investigated in sickle cell disease sufferers. Twenty eight sickle cell anaemia subjects were recruited for the study. Five millilitres of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), total antioxidant enzymes (TAE) activity, malondialdehyde concentration ([MDA]), RBC count, [Hb], PCV, MCHC, MCV, MCH, percent irreversibly sickled cells (%ISC)) and osmotic fragility of red blood cells in the subjects. l-arginine supplementation increased [R] (p