Direct writing of metal nanoparticle films inside sealed microfluidic channels
Direct writing of metal nanoparticle films inside sealed microfluidic channels
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DOI：
10.1021/ac051288j
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发表时间：
2006-01-01
影响因子：
7.4
通讯作者：
Cremer, PS
中科院分区：
文献类型：
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作者：
Castellana, ET;Kataoka, S;Cremer, PS
在这里，我们展示了在密封的PDMS/TiO 2/玻璃微流体装置内图案化任意几何形状的Ag纳米颗粒膜的能力。该技术可以在室温下温和条件下与水溶液一起使用。首先将6 nm的TiO 2膜沉积到平面派热克斯或二氧化硅基底上，随后将其结合到PDMS模具上。然后通过该装置暴露UV光，以从水溶液中还原Ag+，从而产生单层厚的Ag纳米颗粒膜。我们证明，这种芯片上的沉积方法可以利用在一个平行的方式来合成不同尺寸的纳米粒子，通过独立控制在每个微通道中的膜形成的溶液条件。薄膜的形态进行了检查，原子力显微镜，结果表明，纳米粒子的大小是敏感的溶液pH值。此外，我们说明了这些膜的生物功能与配体蛋白质捕获的能力。结果表明，这可以很好地区分地址和背景。该技术似乎是相当通用的，并且Pd、Cu和An的膜也可以被图案化。
Herein we demonstrate the ability to pattern Ag nanoparticle films of arbitrary geometry inside sealed PDMS/ TiO2/glass microfluidic devices. The technique can be employed with aqueous solutions at room temperature under mild conditions. A 6 nm TiO2 film is first deposited onto a planar Pyrex or silica substrate, which is subsequently bonded to a PDMS mold. UV fight is then exposed through the device to reduce Ag+ from an aqueous solution to create a monolayer-thick film of Ag nanoparticles. We demonstrate that this on-chip deposition method can be exploited in a parallel fashion to synthesize nanoparticles of varying size by independently controlling the solution conditions in each microchannel in which the film is formed. The film morphology was checked by atomic force microscopy, and the results showed that the size of the nanoparticles was sensitive to solution pH. Additionally, we illustrate the ability to biofunctionalize these films with ligands for protein capture. The results indicated that this could be done with good discrimination between addressed locations and background. The technique appears to be quite general, and films of Pd, Cu, and An could also be patterned.