Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study
Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study
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DOI：
10.1097/hjh.0000000000001927
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发表时间：
2019-04-01
影响因子：
4.9
通讯作者：
Borghi, Claudio
中科院分区：
文献类型：
--
作者：
Cicero, Arrigo F. G.;Fogacci, Federica;Borghi, Claudio
目的：以往的证据表明，高的低密度脂蛋白胆固醇（LDL-C）和血清尿酸（SUA）水平是内皮功能障碍和血管老化的危险因素。我们研究的目的是评估SUA，LDL-C和高血压事件之间的短期相互作用，在一个样本的整体healthyindividuals.Methods：在2018年1月，我们选择了从一般数据库的Brisighella心脏研究四组年龄和性别匹配的非高血压个体与不同水平的LDL-C和SUA水平，并在2008年人口调查检查。偶发性高血压被定义为收缩压升高超过140 mmHg和/或舒张压升高超过90 mmHg和/或开始降压治疗。在调整了年龄、性别、基线血压、高血压家族史、吸烟状况、BMI和体力活动强度的模型中，与基线LDL-C和SUA水平正常的个体相比，高血压发生的风险比为1.14 [95%置信区间（95% CI）0.87-1.55]对于孤立性高LDL-C水平的个体，1.55（95% CI 0.96-2.48）对于孤立性高SUA水平的个体和1.57（95%CI 1.20-2.15）对于SUA和LDL-C水平均较高的个体。在总体健康人群样本中，当前存在的次优LDL-C和SUA值与发生高血压的风险增加相关。
Objective: Previous evidence suggest that high low-density lipoprotein cholesterol (LDL-C) and serum uric acid (SUA) levels are risk factors for endothelial dysfunction and vascular ageing. The aim of our study was to evaluate the short-term interaction between SUA, LDL-C and incident hypertension in a sample of overall healthy individuals.Methods: In January 2018, we selected from the general database of the Brisighella Heart Study four groups of age and sex-matched nonhypertensive individuals with different levels of LDL-C and SUA level and examined during the 2008 population survey. Incident hypertension has been defined as the increase of SBP values over 140 mmHg and/or of DBP over 90 mmHg and or the beginning of an antihypertensive treatment.Results: In a model adjusted for age, sex, baseline blood pressure, family history of hypertension, smoking status, BMI and physical activity intensity, hazard rations for hypertension development compared with individuals with baseline normal LDL-C and SUA levels are 1.14 [95% confidence interval (95% CI) 0.87-1.55] for individuals with isolated high LDL-C level, 1.55 (95% CI 0.96-2.48) for individuals with isolated high SUA level and 1.57 (95% CI 1.20-2.15) for individuals with both high SUA and LDL-C levels.Conclusion: In an overall healthy population sample, the contemporary presence of suboptimal LDL-C and SUA values is associated with an increased risk to develop hypertension.