Neurogenesis in the nematode Caenorhabditis elegans.
Neurogenesis in the nematode Caenorhabditis elegans.
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DOI：
10.1895/wormbook.1.12.2
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发表时间：
2010-10-04
期刊：
影响因子：
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通讯作者：
Hobert, Oliver
中科院分区：
文献类型：
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作者：
Hobert, Oliver
神经系统在数量（302 个神经元和 56 个神经胶质细胞 = 雌雄同体体细胞的 37%）和多样性（118 个形态上不同的神经元类别）方面代表了线虫中最复杂的组织。每种神经元类型的谱系和形态已被详细描述，几乎所有神经元都以荧光报告基因的形式存在神经元命运标记。以高分辨率对神经元进行“表型”分析的能力，加上秀丽隐杆线虫对基因突变分析的适应性，使秀丽隐杆线虫神经系统成为阐明构建神经系统的基因调控程序本质的主要模型系统，这是发育神经生物学的核心问题。讨论了一些涉及神经元谱系决定和神经元分化的调节基因，我将尝试在这篇综述中阐明秀丽隐杆线虫神经元发育的一些一般原则。这些原则可能在整个系统发育过程中都是保守的。
The nervous system represents the most complex tissue of C. elegans both in terms of numbers (302 neurons and 56 glial cells = 37% of the somatic cells in a hermaphrodite) and diversity (118 morphologically distinct neuron classes). The lineage and morphology of each neuron type has been described in detail and neuronal fate markers exists for virtually all neurons in the form of fluorescent reporter genes. The ability to "phenotype" neurons at high resolution combined with the amenability of C. elegans to genetic mutant analysis make the C. elegans nervous system a prime model system to elucidate the nature of the gene regulatory programs that build a nervous system-a central question of developmental neurobiology. Discussing a number of regulatory genes involved in neuronal lineage determination and neuronal differentiation, I will try to carve out in this review a few general principles of neuronal development in C. elegans. These principles may be conserved across phylogeny.