Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes
Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes
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DOI：
10.3324/haematol.2014.118679
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发表时间：
2015-05-01
期刊：
影响因子：
10.1
通讯作者：
Uhrberg, Markus
中科院分区：
文献类型：
--
作者：
Hejazi, Maryam;Manser, Angela R.;Uhrberg, Markus
众所周知，自然杀伤细胞介导髓性白血病的抗白血病反应，但其在骨髓增生异常综合征中的作用尚不清楚。这里，在一组新诊断的患者（n=75）中，发现了广泛的结构和功能的自然杀伤细胞缺陷。一个亚组患者（13%）外周血自然杀伤细胞选择性缺乏（计数）
Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional natural killer cell defects were identified. One subgroup of patients (13%) had a selective deficiency of peripheral natural killer cells (count