Humoral Response to the Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis
Humoral Response to the Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis
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DOI：
10.2215/cjn.03500321
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发表时间：
2021-07-01
影响因子：
9.8
通讯作者：
Shashar, Moshe
中科院分区：
文献类型：
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作者：
Grupper, Ayelet;Sharon, Nechama;Shashar, Moshe
背景和目的2019冠状病毒病（COVID-19）与维持性血液透析患者的较高发病率和死亡率相关。透析患者往往对感染或疫苗接种的免疫反应降低。我们的目的是评估，第一次尽我们所知，体液免疫接种后的BNT 162 b2疫苗在维持性血液透析患者和相关的因素与it.Design，设置，参与者，和测量研究包括56例维持性血液透析（透析组）和对照组由95名医护人员。所有参与者均接种了两剂BNT 162 b2（Pfizer-BioNTech）疫苗。在接种第二剂疫苗后30天内，使用Abbott公司的Quant II IgG抗刺突型严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）检测试剂盒进行血清学检测。结果对照组所有受试者均产生抗体应答，透析组阳性应答率为96%（54/56）。透析组的IgG水平（中位数，2900;四分位数间距，1128-5651）显着低于对照组（中位数，7401;四分位数间距，3687- 15，471）。Mann-Whitney U检验表明这种差异具有统计学意义（U=1238; P
Background and objectives Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients on maintenance hemodialysis and the factors associated with it.Design, setting, participants, & measurements The study included 56 patients on maintenance hemodialysis (dialysis group) and a control group composed of 95 health care workers. All participants had received two doses of the BNT162b2 (Pfizer-BioNTech) vaccine. The serology testing was done using Quant II IgG anti-Spike severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay by Abbott a median of 30 days after receipt of the second dose of the vaccine.Results All subjects in the control group developed an antibody response compared with 96% (54 of 56) positive responders in the dialysis group. The IgG levels in the dialysis group (median, 2900; interquartile range, 1128-5651) were significantly lower than in the control group (median, 7401; interquartile range, 3687-15,471). A Mann-Whitney U test indicated that this difference was statistically significant (U=1238; P