Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.
Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.
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结外 NK/T 细胞淋巴瘤，子宫颈鼻型：病例报告。
DOI：
10.1002/dc.23439
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hirata S.
中科院分区：
文献类型：
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作者：
Omori M;Oishi N;Nakazawa T;Nakazawa K;Mitsumori T;Yuminamochi T;Kirito K;Hirata S.
我们报告了一例罕见的结外 NK/T 细胞淋巴瘤，即子宫颈鼻型，其细胞学特征类似于宫颈癌。一名 65 岁女性因阴道流血就诊。妇科检查发现子宫颈有一个巨大的肿瘤。传统的巴氏染色宫颈涂片显示细胞过多，由许多大小不一的粘性簇组成，模仿上皮肿瘤，具有坏死和炎症背景。还鉴定出了少量单独分散的细胞。这些分散的细胞表现出多形性、经常分裂或马蹄形的细胞核和苍白的细胞质。活检标本显示非典型细胞弥漫性生长，具有血管中心模式。存在广泛的坏死和炎性细胞浸润。存在大量有丝分裂像。原位杂交显示肿瘤细胞 CD45RO、CD3ε、CD56、颗粒酶 B、TIA-1、CD7 和 Epstein-Barr 病毒 (EBV) 编码的小 RNA (EBER) 呈阳性，而细胞角蛋白、嗜铬粒蛋白 A、突触素、CD4、CD5、CD8、CD20 和 CD30 呈阴性。基于这些发现，该肿瘤被诊断为结外 NK/T 细胞淋巴瘤，子宫颈鼻型。诊断。细胞病理醇。 2016；44：430–433。 © 2016 Wiley 期刊公司。
We report a rare case of extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65‐year‐old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou‐stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. A small number of individually scattered cells were also identified. These scattered cells showed pleomorphic, often cleaved, or horseshoe‐shaped nuclei and pale cytoplasm. Biopsy specimens revealed a diffuse growth of atypical cells with an angiocentric pattern. Extensive necrosis and infiltration of inflammatory cells were present. There were numerous mitotic figures. The tumor cells were positive for CD45RO, CD3ε, CD56, granzyme B, TIA‐1, CD7, and Epstein–Barr virus (EBV)‐encoded small RNA (EBER) by in situ hybridization, and negative for cytokeratin, chromogranin A, synaptophysin, CD4, CD5, CD8, CD20, and CD30. Based on these findings, this tumor was diagnosed as extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix. Diagn. Cytopathol. 2016;44:430–433. © 2016 Wiley Periodicals, Inc.