Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.
Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.
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DOI：
10.1128/aac.01144-13
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发表时间：
2013-09-01
影响因子：
4.9
通讯作者：
Jorgensen, James H
中科院分区：
文献类型：
--
作者：
Lewis, James S 2nd;Wiederhold, Nathan P;Jorgensen, James H
我们报告了一例光滑念珠菌念珠菌血症病例，该患者在开始治疗后8天内对米卡芬净产生耐药性，该患者既往没有接触过棘白菌素或其他已知的临床或微生物学失败风险因素。前和后耐药分离株被证实是同基因的，和已知的热点测序赋予棘白菌素耐药性揭示了一个苯丙氨酸缺失密码子659内FKS 2。
We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre- and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.