Reduced neutralization and Fc effector function to Omicron subvariants in sera from SARS‐CoV‐1 survivors after two doses of CoronaVac plus one dose subunit vaccine
Reduced neutralization and Fc effector function to Omicron subvariants in sera from SARS‐CoV‐1 survivors after two doses of CoronaVac plus one dose subunit vaccine
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DOI：
10.1002/jmv.29136
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发表时间：
2023-10
影响因子：
12.7
通讯作者：
Danying Chen;Xinglin Li;Xiaohua Hao;Yaruo Qiu;Yanjun Song;Hui Sun;Yongmei Liu;Juan Du;Yuanyuan Zhang;Fan Xiao;Chuan Song;Yonghong Yan;Rui Song;Xi Wang;Xuesen Zhao;Ronghua Jin
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作者：
Danying Chen;Xinglin Li;Xiaohua Hao;Yaruo Qiu;Yanjun Song;Hui Sun;Yongmei Liu;Juan Du;Yuanyuan Zhang;Fan Xiao;Chuan Song;Yonghong Yan;Rui Song;Xi Wang;Xuesen Zhao;Ronghua Jin
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）Omicron携带超过30种刺突蛋白突变，并表现出大量的免疫逃避。尽管先前的研究表明BNT 162 b2信使RNA疫苗在SARS-CoV-1感染的幸存者中诱导了有效的交叉进化枝泛肉瘤病毒中和抗体，但在SARS-CoV-1幸存者中诱导的这些交叉反应性抗体对Omicron亚变体的中和活性和Fc介导的效应子功能仍然在很大程度上未知。在这项研究中，在SARS-CoV-1恢复期和健康个体中表征了第三剂疫苗接种加强的抗体的中和活性和Fc介导的效应子功能。在接受三剂疫苗接种方案的SARS-CoV-1幸存者中观察到了有效的交叉进化枝广泛中和抗体，该方案包括两剂CoronaVac引发剂量，随后是一剂蛋白亚单位疫苗ZF 2001的加强剂量。然而，诱导的抗体表现出降低的中和和受损的Fc效应子功能，靶向多个Omicron亚变体。重要的是，这些数据还支持SARS-CoV-1感染导致的免疫印记可能加剧Omicron亚变体的中和活性和Fc介导的效应子功能的损害，并为未来的疫苗接种策略提供了宝贵的信息。
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron harbors more than 30 mutations of the spike protein and exhibits substantial immune evasion. Although previous study indicated that BNT162b2 messenger RNA vaccine induces potent cross‐clade pan‐sarbecovirus neutralizing antibodies in survivors of the infection by SARS‐CoV‐1, the neutralization activity and Fc‐mediated effector functions of these cross‐reactive antibodies elicited in SARS‐CoV‐1 survivors to Omicron subvariants still remain largely unknown. In this study, the neutralization activity and Fc‐mediated effector functions of antibodies boosted by a third dose vaccination were characterized in SARS‐CoV‐1 convalescents and healthy individuals. Potent cross‐clade broadly neutralizing antibodies were observed in SARS‐CoV‐1 survivors who received a three‐dose vaccination regimen consisting of two priming doses of CoronaVac followed by one booster dose of the protein subunit vaccine ZF2001. However, the induced antibodies exhibited both reduced neutralization and impaired Fc effector functions targeting multiple Omicron subvariants. Importantly, the data also support the notion that immune imprints resulted from SARS‐CoV‐1 infection may exacerbate the impairment of neutralization activity and Fc‐mediated effector functions to Omicron subvariants and provided invaluable information to vaccination strategy in future.