Color blindness not closely linked to bipolar illness. Report of a new pedigree series.
Color blindness not closely linked to bipolar illness. Report of a new pedigree series.
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色盲与双相情感障碍没有密切关系。
DOI：
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发表时间：
1979
影响因子：
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通讯作者：
William E. Bunney
中科院分区：
文献类型：
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作者：
Elliot S. Gershon;Targum Sd;Steven Matthysse;William E. Bunney
由于先前的研究表明两者之间普遍存在密切的联系，一组新的双相躁狂抑郁症谱系患者被美国国家精神卫生研究所（National Institute of Mental Health）的内部研究项目评估了双相疾病与红绿色盲之间的联系。采用家系研究方法，对6个家谱进行了调查。使用多代程序进行分析，并考虑到可变外显率。作为一个普遍的发现，可以明确地排除密切联系。因此，双相情感障碍和相关疾病通常不是由靠近人类x染色体的蛋白/多肽区域的单个主要基因传播的。
A new pedigree series of bipolar manic-depressive patients admitted to the National Institute of Mental Health intramural research program was evaluated for linkage between bipolar illness and red-green color blindness, since previous studies had indicated that close linkage was generally present. Using family study methods, six informative pedigrees were investigated. Analysis was performed using a multigenerational procedure and taking into account variable penetrance. Close linkage could be definitively ruled out as a general finding. Bipolar and related illnesses are thus not generally transmitted by a single major gene close to the protan/deutan region of the human X-chromosome.