Pressure ulcers -: A role for thymosin β4
Pressure ulcers -: A role for thymosin β4
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DOI：
10.1196/annals.1415.049
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Godschalk, Michael Francis
中科院分区：
文献类型：
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作者：
Godschalk, Michael Francis
高达14%的急性住院患者发生压疮。它们会引起疼痛，降低生活质量，增加发病率，延长住院时间。治疗包括控制疼痛、营养支持、缓解压力、去除失活组织，以及使用敷料和药物，提供一个可以愈合的环境。即使采用最佳治疗方法，压疮也可能需要数月才能愈合。胸腺素- 4正被研究用于治疗压疮。胸腺素- 4具有伤口愈合和抗炎的特性。它被认为是通过促进角质细胞和内皮细胞迁移、增加胶原沉积和刺激血管生成来发挥其治疗作用的。一项对大鼠全层伤口模型的研究表明，胸腺素β 4治疗可增加胶原沉积和血管生成，并刺激角化细胞迁移和再上皮化。如果胸腺素- 4能缩短愈合时间，这将代表压疮治疗的重大进步。
Pressure ulcers occur in up to 14% of acute hospitalizations. They cause pain, decreased quality of life, increased morbidity, and prolonged hospitalizations. Treatment includes pain control, nutritional support, relieving pressure, removing devitalized tissue, and by using dressings and medications, providing an environment in which healing can occur. Even with optimal treatment, pressure ulcers may take months to heal. Thymosin beta 4 is being investigated as a treatment for pressure ulcers. Thymosin beta 4 has wound healing and anti-inflammatory properties. It is thought to exert its therapeutic effect through promotion of keratinocyte and endothelial cell migration, increased collagen deposition, and stimulation of angiogenesis. A study in a rat full-thickness wound model showed that treatment with thymosin beta 4 increased collagen deposition and angiogenesis and stimulated keratinocyte migration and reepithelialization. If thymosin beta 4 decreases healing time, this would represent a significant advance in the treatment of pressure ulcers.