Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice
Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice
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DOI：
10.1016/j.brainres.2007.02.049
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发表时间：
2007-05
期刊：
影响因子：
2.9
通讯作者：
S. Uchida;Hisahiro Umeeda;A. Kitamoto;S. Masushige;S. Kida
中科院分区：
文献类型：
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作者：
S. Uchida;Hisahiro Umeeda;A. Kitamoto;S. Masushige;S. Kida
系统性色氨酸的消耗是研究5-羟色胺减少对认知影响的重要工具。事实上，先前的报告表明，TRP的急性消耗会导致人类和啮齿动物的记忆损伤。从营养学的角度来看，研究慢性限制l-色氨酸（TRP）对学习和记忆形成的影响具有重要意义。在这项研究中，我们研究了长期食用低TRP饮食对小鼠记忆形成的影响。具体来说，我们评估了喂食trp限制饮食至少1个月的小鼠形成情境恐惧、线索恐惧、条件性味觉厌恶和空间记忆的能力。trp限制小鼠表现出依赖海马体的情境恐惧记忆形成受损。相比之下，这些小鼠在莫里斯水迷宫测试中表现出正常的海马体依赖的空间记忆，以及杏仁核依赖的提示恐惧和条件性味觉厌恶记忆。因此，饮食TRP限制似乎导致小鼠海马依赖性情境恐惧记忆形成的选择性损伤。
The depletion of systemic tryptophan is an important tool to study the effects of reduced 5-HT on cognition. Indeed, previous reports indicated that acute depletion of TRP leads to a memory impairment in human subjects and rodents. From the view of nutrition, it is important to investigate the effects of chronic limitation of l-tryptophan (TRP) on learning and memory formation. In this study, we examined the effects of chronic consumption of a low TRP diet on memory formation in mice. Specifically, we assessed the ability to form contextual fear, cued fear, conditioned taste aversion, and spatial memories in mice fed a TRP-limited diet for at least 1 month. TRP-limited mice showed impaired formation of contextual fear memory that is hippocampus-dependent. In contrast, these mice showed normal hippocampus-dependent spatial memory in the Morris water maze test, as well as in cued fear and conditioned taste aversion memories, which are amygdala-dependent memory processes. Thus, dietary TRP restriction appears to result in selective impairments in hippocampus-dependent contextual fear memory formation in mice.