Endocrine mucin-producing sweat gland carcinoma: a study of three cases and CK8, CK18 and CD5/6 immunoexpression
Endocrine mucin-producing sweat gland carcinoma: a study of three cases and CK8, CK18 and CD5/6 immunoexpression
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DOI：
10.1111/cup.12512
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发表时间：
2015-08-01
影响因子：
1.7
通讯作者：
Cassarino, David S.
中科院分区：
文献类型：
--
作者：
Fernandez-Flores, Angel;Cassarino, David S.
内分泌黏液分泌型汗腺癌是一种皮肤附件肿瘤，文献报道甚少。我们只确定了先前报告的29例病例。所有病例均具有一定的临床形态学和免疫组织化学特征。在免疫组化标记物中，细胞角蛋白5/6、8和18 （CK5/6、CK8和CK18）此前未在该肿瘤中进行研究。虽然有关于细胞角蛋白Cam5.2的研究，但目前我们知道这个标记并不对应于抗体CK8/18，而是对应于CK7和CK8。我们用18种免疫染色法研究了3例内分泌黏液分泌型汗腺癌。我们的病例显示免疫谱CK8+， CK18+, CK5/6-（或仅局灶阳性），CK7+, GCDFP-15+（2例），雌激素受体+，孕激素受体+，HER2-，神经元特异性烯醇酶+（2例），抗突触素+，嗜铬粒蛋白A +， CD56变量（1例+，1例-），CD57-，抗人D2-40-（2例），p63-或局灶阳性，平滑肌肌动蛋白+表达模式可变，平滑肌肌球蛋白重链在一些结节的外周不连续层表达。但大多数国家都没有。
Endocrine mucin-producing sweat gland carcinoma is a cutaneous adnexal tumor that is rarely reported in the literature. We identified only 29 previously reported cases. All these cases share some clinical morphologic and immunohistochemical features. Among the immunohistochemical markers, cytokeratins 5/6, 8 and 18 (CK5/6, CK8 and CK18) had not been previously studied in this tumor. Although studies with cytokeratin Cam5.2 exist, we know at present that this marker does not correspond to antibodies CK8/18, but rather to CK7 and CK8. We studied three examples of endocrine mucin-producing sweat gland carcinoma with 18 immunostains. Our cases showed an immunoprofile CK8+, CK18+, CK5/6- (or only focally positive), CK7+, GCDFP-15+ (2 cases), estrogen receptor+, progesterone receptor+, HER2-, neuron-specific enolase+(2 cases), anti-synaptophysin+, chromogranin A +, CD56 variable (1 case +, 1 case-), CD57-, anti-human D2-40- (two cases), p63- or focally positive, smooth muscle actin+with variable pattern of expression and smooth muscle myosin heavy chain expressed in a peripheral discontinuous layer in some nodules, but absent in most.