Ultrastructural changes in the edematous central nervous system. II. Cold-induced edema.
Ultrastructural changes in the edematous central nervous system. II. Cold-induced edema.
复制标题
水肿中枢神经系统的超微结构变化。
作者：
J. Lee;L. Bakay
自从1948年Hass和Taylor引入了一种容易复制的技术以来，局部皮质冷冻引起的脑水肿已经成为一种实验操作方法。1这项技术后来得到了改进。2-4对文献的回顾表明，无论冷冻剂和应用部位如何，从不同动物物种获得的结果基本上是相同的，即大脑皮质出现局灶性出血性病变，并伴有受损大脑半球白质的广泛水肿。通过组织学、化学和示踪方法研究的病理变化的细节之前由我们中的一人报告过。5与广泛的冷致水肿的光镜研究不同，超微结构的变化仅由Torack等人研究。6这些作者将他们的电子显微镜检查限制在病变附近的大脑皮层。出于这个原因，他们的观察不能扩展到
CEREBRAL EDEMA produced by localized cortical freezing has become an experimental modus operandi since the introduction of an easily reproducible technique by Hass and Taylor in 1948. 1 This technique was refined subsequently. 2-4 A review of the literature shows that, regardless of freezing agents and sites of application, the results obtained from different animal species are essentially the same, namely, a focal hemorrhagic lesion in the cerebral cortex accompanied by wide-spread edema in the white matter of the damaged hemisphere. The details of pathological changes studied by histological, chemical, and tracer methods were previously reported by one of us. 5 In contrast to the extensive light microscopic investigation of cold-induced edema, the ultrastructural changes have been studied only by Torack et al. 6 These authors limited their electron microscopic examination to the cerebral cortex adjacent to the lesion. For this reason their observations cannot be extended to