EFFECTS OF HIPPOCAMPAL LESION ON CARDIOVASCULAR, ADRENOCORTICAL AND BEHAVIORAL RESPONSE PATTERNS IN MICE
EFFECTS OF HIPPOCAMPAL LESION ON CARDIOVASCULAR, ADRENOCORTICAL AND BEHAVIORAL RESPONSE PATTERNS IN MICE
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DOI：
10.1016/0031-9384(77)90014-2
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发表时间：
1977-01-01
影响因子：
2.9
通讯作者：
HENRY, JP
中科院分区：
文献类型：
--
作者：
ELY, DL;GREENE, EG;HENRY, JP
海马损伤的小鼠在领土情况下的社会互动过程中出现高血压、低心率和高血浆皮质酮。海马动物保持在一个nonterritorial的情况下，最小的社会互动没有表现出显着的心血管或血浆皮质酮的变化相比，未手术的控制或皮质病变的控制。这些具有社会性互动的海马动物没有形成社会等级，也没有对置于殖民地的入侵者做出积极的反应。海马体可能参与社会行为的维持，而社会行为又可能调节自主神经系统的活动。
Mice with a hippocampal lesion developed high blood pressure, low heart rates, and high plasma corticosterone during social interaction in a territorial situation. Hippocampal animals kept in a nonterritorial situation with minimal social interaction did not show significant cardiovascular or plasma corticosterone changes as compared to unoperated controls or cortically lesioned controls. The socially interacting hippocampal animals failed to develop a social hierarchy and did not respond aggressively to an intruder placed in the colony. The hippocampus may be involved in the maintenance of social behavior which in turn may modulate autonomic nervous system activity.