Mechanical deformation of compressible chromatographic columns
Mechanical deformation of compressible chromatographic columns
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DOI：
10.1021/bp020051v
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发表时间：
2002-05-01
影响因子：
2.9
通讯作者：
Fernandez, EJ
中科院分区：
文献类型：
--
作者：
Keener, RN;Maneval, JE;Fernandez, EJ
提出了可压缩色谱柱机械变形的一维模型。该模型基于线弹性和连续介质力学，并与更完整的二维模型和通过核磁共振成像方法测量的一维孔隙度剖面进行比较。该模型提供了放大过程中压缩和壁支撑效果的定量描述。还制定了一个简单的标准，用于衡量墙支撑的重要性作为直径和长度的函数。尽管该模型仅考虑机械变形，但可以包括流动压缩，并且此处提出的验证表明，更完整的模型对于预测规模和纵横比对可压缩柱压力-流动行为的影响可能很有价值。
A one-dimensional model of mechanical deformation of compressible chromatography columns is presented. The model is based on linear elasticity and continuum mechanics and is compared to a more complete two-dimensional model and one-dimensional porosity profiles measured by NMR imaging methods. The model provides a quantitative description of compression and the effects of wall support during scale-up. A simple criterion for the significance of wall support as a function of both diameter and length is also developed. Although the model accounts only for mechanical deformation, flow compression can be included, and validation presented here suggests that a more complete model may be valuable for anticipating the effects of scale and aspect ratio on pressure-flow behavior of compressible columns.