Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
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发表时间：
2005-11
影响因子：
2
通讯作者：
H. Nagasawa;Y. Uto;Hideyuki Sasaki;Natsuko Okamura;Aya Murakami;S. Kubo;K. Kirk;H. Hori
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文献类型：
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作者：
H. Nagasawa;Y. Uto;Hideyuki Sasaki;Natsuko Okamura;Aya Murakami;S. Kubo;K. Kirk;H. Hori
GC蛋白(人组特异性成分，一种维生素D结合蛋白或GC球蛋白)具有重要的生理功能，包括参与维生素D的运输和储存，清除细胞外G-肌动蛋白，增强C5a对炎症中性粒细胞的趋化活性和巨噬细胞激活(由GalNAc修饰的GC蛋白(GcMAF)介导)。本文主要从GC基因分型和GcMAF前体活性两个方面对GC蛋白的结构和功能进行了综述。在我们自己研究的基础上，讨论了“GcMAF作为药物发现的目标”的研究策略。
The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5a for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy "GcMAF as a target for drug discovery" is included, based on our own research.