Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans
Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans
复制标题
亚牛磺酸通过秀丽隐杆线虫的应激反应因子 DAF-16/FOXO 和 SKN-1/NRF2 促进寿命和应激耐受性
DOI：
10.1039/c9fo02000d
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发表时间：
2020-01-01
期刊：
影响因子：
6.1
通讯作者：
Zhou, Qinghua
中科院分区：
文献类型：
--
作者：
Wan, Qin-Li;Fu, Xiaodie;Zhou, Qinghua
亚牛磺酸是一种重要的含硫非肽氨基酸，是牛磺酸的前体，也是一种抗氧化剂。我们以前的研究表明亚牛磺酸水平与秀丽隐杆线虫的衰老有关。elegans）。然而，亚牛磺酸是否在C. elegans和机制仍然不确定。在此，我们发现亚牛磺酸增强了C.优雅的我们的研究结果表明，亚牛磺酸调节多种途径，并导致一些年龄相关基因的上调，以延长寿命。我们还发现，应激反应相关的转录因子α-16/FOXO和SKN-1/NRF 2有助于亚牛磺酸赋予的有益寿命。此外，我们的研究结果表明，亚牛磺酸通过调节胰岛素/IGF-1信号通路（IIS），生殖信号通路和DR样机制诱导寿命延长。此外，我们的研究结果还表明，线粒体功能在亚牛磺酸诱导的寿命延长中也起着至关重要的作用。这些结果表明亚牛磺酸能延缓C.这至少部分是由于其抗氧化活性，这反过来又调节IIS、生殖和DR相关途径，从而诱导转录因子SKN-16和SKN-1的活性。
Hypotaurine, an important sulfur-containing and nonpeptidic amino acid, is a precursor of taurine and an antioxidant. Our previous study indicated that hypotaurine levels are associated with the ageing of Caenorhabditis elegans (C. elegans). However, whether hypotaurine plays a role in the lifespan regulation of C. elegans and the mechanism remains undetermined. Here, we found that hypotaurine enhances oxidative stress resistance and ameliorates ageing in C. elegans. Our results show that hypotaurine regulates a variety of pathways and leads to the upregulation of some age-related genes to extend lifespan. We also found that the stress response-related transcription factors DAF-16/FOXO and SKN-1/NRF2 contribute to the beneficial longevity conferred by hypotaurine. Moreover, our results demonstrate that hypotaurine induced lifespan extension by regulating the insulin/IGF-1 signaling (IIS) pathway, the reproductive signaling pathway and DR-like mechanisms. Additionally, our results also indicated that mitochondrial function also plays a crucial role in the lifespan extension induced by hypotaurine. Taken together, these data indicate that hypotaurine delays the ageing of C. elegans, due, at least in part, to its antioxidant activity, which in turn regulates IIS, and reproductive and DR-related pathways, thereby inducing the activity of the transcription factors DAF-16 and SKN-1.