Fractionation of memory in medial temporal lobe amnesia
Fractionation of memory in medial temporal lobe amnesia
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DOI：
10.1016/j.neuropsychologia.2006.10.011
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Cipolotti, Lisa
中科院分区：
文献类型：
--
作者：
Bird, Chris M.;Shallice, Tim;Cipolotti, Lisa
我们报告了两个有记忆障碍的患者(RH和JC)的顺行记忆功能的全面调查。RH有明显的选择性右侧海马区损害的神经放射学证据，除了选择性记忆损害外，还有完整的认知特征。JC，有神经放射学证据表明，由于心脏骤停导致缺氧后双侧海马区受损。除了全身性健忘症外，他还有命名和“执行”方面的困难，这表明萎缩范围超出了海马区。他们的表现与之前报道的一名海马体健忘症患者的表现进行了比较，该患者在严重的语言和地形性记忆障碍的背景下对面孔表现出保留的记忆和熟悉[VC；Cipolotti，L.，Bird，C.，Good，T.，T.，Macmanus，D.，Rdge，P.，&Shallice，T.(2006)。密集海马区健忘症患者的记忆和熟悉：一项个案研究。神经心理学，44,489-506。]这些患者接受了使用语言材料(单词)和两种非语言材料(面孔和建筑物)的实验测试。在实验测试中，使用接收者操作特征分析来估计回忆和熟悉性对再认绩效的贡献。RH保留了言语识别记忆。有趣的是，她的人脸识别记忆也幸免于难，而地形识别记忆则受到了损害。JC在所有类型的语言和非语言材料上都受到了损害。在这两个患者中，记忆缺陷总是与熟悉性缺陷相关。JC的数据表明，有必要对缺氧后明显选择性海马区损伤的患者进行全面的认知调查。来自RH的数据表明，右侧海马体对于记忆和熟悉地形材料是必要的，而左侧海马体足以支持这些过程，至少对某些类型的言语材料来说是如此。海马体以外的区域可能会充分削弱人脸识别记忆。(C)2006爱思唯尔有限公司。保留所有权利。
We report a comprehensive investigation of the anterograde memory functions of two patients with memory impairments (RH and JC). RH had neuroradiological evidence of apparently selective right-sided hippocampal damage and an intact cognitive profile apart from selective memory impairments. JC, had neuroradiological evidence of bilateral hippocampal damage following anoxia due to cardiac arrest. He had anomic and "executive" difficulties in addition to a global amnesia, suggesting atrophy extending beyond hippocampal regions. Their performance is compared with that of a previously reported hippocampal amnesic patient who showed preserved recollection and familiarity for faces in the context of severe verbal and topographical memory impairment [VC; Cipolotti, L., Bird, C., Good, T., Macmanus, D., Rudge, P., & Shallice, T. (2006). Recollection and familiarity in dense hippocampal amnesia: A case study. Neuropsychologia, 44, 489-506.] The patients were administered experimental tests using verbal (words) and two types of non-verbal materials (faces and buildings). Receiver operating characteristic analyses were used to estimate the contribution of recollection and familiarity to recognition performance on the experimental tests. RH had preserved verbal recognition memory. Interestingly, her face recognition memory was also spared, whilst topographical recognition memory was impaired. JC was impaired for all types of verbal and non-verbal materials. In both patients, deficits in recollection were invariably associated with deficits in familiarity. JC's data demonstrate the need for a comprehensive cognitive investigation in patients with apparently selective hippocampal damage following anoxia. The data from RH suggest that the right hippocampus is necessary for recollection and familiarity for topographical materials, whilst the left hippocampus is sufficient to underpin these processes for at least some types of verbal materials. Face recognition memory may be adequately subserved by areas outside of the hippocampus. (c) 2006 Elsevier Ltd. All rights reserved.