Principal components analysis of a large cohort with Tourette syndrome
Principal components analysis of a large cohort with Tourette syndrome
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DOI：
10.1192/bjp.bp.107.039909
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发表时间：
2008-07-01
影响因子：
10.5
通讯作者：
Pauls, David L.
中科院分区：
文献类型：
--
作者：
Robertson, Mary M.;Althoff, Robert R.;Pauls, David L.
背景Tourette综合征是一种异质性家族性疾病，其遗传机制尚不清楚。方法对410例Tourette综合征患者的症状数据进行聚类分析和主成分分析，结果共发现5个因子，其特征为：（1）社交不恰当行为和其他复杂的发声性抽动，（2）复杂的运动性抽动，（3）简单的抽动，（4）复杂的运动性抽动，（5）复杂的运动性抽动，（6）复杂的运动性抽动，（7）复杂的运动性抽动，（8）复杂的运动性抽动。（4）强迫行为;（5）触摸自己。注意缺陷多动障碍患者在因子1和3上的因子分显著高于强迫症和行为障碍患者在因子1- 4上的因子分。结论这些发现增加了越来越多的证据，表明Tourette综合征不是一个单一的疾病，可以分解为更同质的症状成分。利益声明无。资金详情见鸣谢。
BackgroundTourette syndrome is a heterogeneous familial disorder for which the genetic mechanisms are unknown. A better characterisation of the phenotype may help identify susceptibility genes.AimsTo extend previous factor-analytic studies of the syndrome.MethodSymptom data from 410 people with Tourette syndrome were included in agglomerative hierarchical cluster and principal components analyses.ResultsFive factors were observed, characterised by: (1) socially inappropriate behaviours and other complex vocal tics; (2) complex motor tics, (3) simple tics; (4) compulsive behaviours; and (5) touching self. individuals with co-occurring attention-deficit hyperactivity disorder had significantly higher factor scores on Factors 1 and 3, whereas individuals with co-occurring obsessive-compulsive disorder and behaviours had significantly higher factor scores for Factors 1-4.ConclusionsThese findings add to the growing body of evidence that Tourette syndrome is not a unitary condition and can be disaggregated into more homogeneous symptom components. Declaration of interest None. Funding detailed in Acknowledgements.