Characteristics of Patients With Unilateral and Bilateral Meniere's Disease
Characteristics of Patients With Unilateral and Bilateral Meniere's Disease
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DOI：
10.1097/mao.0b013e31826426b9
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发表时间：
2012-09-01
影响因子：
2.1
通讯作者：
Ruckenstein, Michael
中科院分区：
文献类型：
--
作者：
Clemmens, Clarice;Ruckenstein, Michael
目的：评价单侧和双侧梅尼埃病（MD）患者的流行病学差异。背景：MD的诊断是基于临床标准的，其病因尚不清楚。单侧和双侧MD患者特征的差异已经被注意到，但这些研究的诊断标准是可变的。为了描述可能对MD病因有影响的发现，我们研究了严格选择的单侧和双侧MD患者群体。研究设计：前瞻性队列。材料和方法：对可能诊断为MD的患者进行广泛的评估（听力、放射学和免疫学），只有特发性MD患者被纳入本研究。疾病的双侧性基于临床和听力学标准。作为评估一部分的变量进行了统计分析，以确定单侧和双侧组患者的特征是否存在显著差异。结果：双侧疾病患者出现的年龄明显更年轻，个人偏头痛史和MD家族史的发生率明显更高。其他确定的变量均未发现显著差异。结论：双侧MD患者偏头痛发生率较高，且有MD家族史。本文对其发病机制进行了探讨。
Objective: To evaluate epidemiologic differences between patients with unilateral and bilateral Meniere's disease (MD). To evaluate these differences for insights into the possible causes of bilateral MD.Background: The diagnosis of MD is based on clinical criteria, and its cause is unknown. Differences in characteristics of patients with unilateral and bilateral MD have been noted, but these studies' diagnostic criteria have been variable. To delineate findings that might have implications as to the cause of MD, we have studied rigidly selected patient populations with unilateral and bilateral MDStudy Design: Prospective cohort.Materials and Methods: Patients with a potential diagnosis of MD underwent extensive evaluations (audiometric, radiologic, and immunologic), and only patients with idiopathic MD were included in this study. Bilaterality of disease was based on clinical and audiometric criteria. Variables identified as part of the evaluation were subjected to statistical analyses to determine if significant differences existed in the characteristics of patients in the unilateral and bilateral groupsResults: Patients with bilateral disease presented at a significantly younger age and had a significantly higher incidence of a personal history of migraines and a family history of MD. None of the other identified variables were found to be significantly different.Conclusion: Patients with bilateral MD have a higher incidence of migraines and of a family history of MD. Implications as to disease pathogenesis are discussed.