Associations between blood metals and fecundity among women residing in New York State
Associations between blood metals and fecundity among women residing in New York State
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DOI：
10.1016/j.reprotox.2010.09.013
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Jain, Jinesh
中科院分区：
文献类型：
--
作者：
Bloom, Michael S.;Louis, Germaine M. Buck;Jain, Jinesh
微量金属接触可能影响女性生殖健康。为了评估血液中微量金属浓度与女性生育力之间的关系，对99名因怀孕而停止避孕的非妊娠妇女进行了前瞻性随访。参与者完成了基线访谈和每日日记，直到怀孕，或多达12个月经周期的怀孕风险;使用家庭妊娠测试试剂盒。对于80名妇女，全血标本分析砷，镉，铅，镁，镍，硒和锌使用电感耦合等离子体质谱法（ICP-MS）。使用离散时间的考克斯比例风险模型估计妊娠时间。金属浓度一般在人群参考区间内。调整后的模型表明，怀孕的概率增加51.5%，每增加3.60 μ g/L的镁（P=0.062），和减少27.7%，每增加0.54 μ g/L的锌（P=0.114）。研究结果表明，镁和锌可能会影响女性生育力，但在不同的方向。(c)2010爱思唯尔公司All rights reserved.
Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 menstrual cycles at risk for pregnancy; home pregnancy test kits were used. For 80 women, whole blood specimens were analyzed for arsenic, cadmium, lead, magnesium, nickel, selenium and zinc using inductively coupled plasma mass spectrometry (ICP-MS). Time to pregnancy was estimated using Cox proportional hazards models for discrete time. Metal concentrations were generally within population reference intervals. Adjusted models suggest a 51.5% increase in the probability for pregnancy per 3.60 mu g/L increase in Mg (P=0.062), and a 27.7% decrease per 0.54 mu g/L increase in Zn (P=0.114). Findings indicate that Mg and Zn may impact female fecundity, but in varying directions. (c) 2010 Elsevier Inc. All rights reserved.