A Concise Synthesis of (+)-Artemisinin
A Concise Synthesis of (+)-Artemisinin
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DOI：
10.1021/ja3061479
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发表时间：
2012-08-22
影响因子：
15
通讯作者：
Cook, Silas P.
中科院分区：
文献类型：
--
作者：
Zhu, Chunyin;Cook, Silas P.
疟疾是当今世界上医学和经济上最具破坏性的疾病之一。幸运的是，存在一种基于天然产物青蒿素的高效治疗方法。尽管已经开发了几种合成天然产物的方法，但利用低成本化学投入的简化合成尚未实现。在这里，我们报告了一种有效、成本效益高的青蒿素治疗方法。该战略成功的关键是开发了温和的、构建复杂性的反应级联反应，使人们能够使用容易获得、负担得起的环己酮作为关键的起始材料。
Malaria represents one of the most medically and economically debilitating diseases present in the world today. Fortunately, there exists a highly effective treatment based on the natural product artemisinin. Despite the development of several synthetic approaches to the natural product, a streamlined synthesis that utilizes low-cost chemical inputs has yet to materialize. Here we report an efficient, cost-effective approach to artemisinin. Key to the success of the strategy was the development of mild, complexity-building reaction cascades that allowed the use of readily available, affordable cyclohexenone as the key starting material.