Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity.
Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity.
复制标题
促红细胞生成素可以保护培养的皮质神经元，但不能保护星形胶质细胞免受缺氧和 AMPA 毒性的影响。
DOI：
10.1016/s0304-3940(00)01361-6
复制
发表时间：
2000
影响因子：
2.5
通讯作者：
Greenberg,DA
中科院分区：
文献类型：
--
作者：
Sinor,AD;Greenberg,DA
除了众所周知的造血作用外，促红细胞生成素 (Epo) 在某些缺氧缺血性损伤模型中还具有神经营养特性和神经保护作用。为了进一步明确 EPO 神经保护作用的细胞机制，我们研究了 Epo 对培养的大鼠皮质神经元和星形胶质细胞缺氧缺氧的影响，以及对培养的大鼠皮质神经元暴露于兴奋性毒素的影响。 Epo（30 pM）可减少葡萄糖剥夺引起的缺氧引起的神经元细胞死亡，但不会减少星形胶质细胞死亡，并且还减弱 (±)-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸 (AMPA) 的神经毒性作用，但不会减弱其他兴奋毒素的神经毒性作用。 Epo 似乎可以通过对神经元的直接作用来预防脑缺血，这种作用可能部分由 AMPA 受体介导。
In addition to its better-known hemopoietic action, erythropoietin (Epo) has neurotrophic properties and neuroprotective effects in some models of hypoxic-ischemic injury. To define further the cellular mechanisms underlying neuroprotection by Epo, we studied the effects of Epo on hypoxia with glucose deprivation in cultured rat cortical neurons and astroglia and on exposure to excitotoxins in cultured rat cortical neurons. Epo (30 pM) reduced neuronal, but not astroglial, cell death from hypoxia with glucose deprivation, and also attenuated the neurotoxic effect of (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), but not other excitotoxins. Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors.