Racial differences in well-being and cancer concerns in prostate cancer patients
Racial differences in well-being and cancer concerns in prostate cancer patients
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DOI：
10.1007/s11764-011-0170-1
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发表时间：
2011-06-01
影响因子：
3.7
通讯作者：
Jayadevappa, Ravishankar
中科院分区：
文献类型：
--
作者：
Chhatre, Sumedha;Wein, Alan J.;Jayadevappa, Ravishankar
背景：我们分析了临床上局限性前列腺癌患者的身体幸福感、社会/家庭幸福感、功能幸福感、情感幸福感以及前列腺癌相关问题的种族差异。参与者在基线和3、6、12和24个月的随访时完成了癌症治疗-前列腺功能评估(FACT-P)工具。为了确定在所有功能指标(身体幸福感、社会/家庭幸福感、功能幸福感、情感幸福感和前列腺癌特有问题)上组内和组内的差异，我们使用重复测量ANOVA。结果除教育、收入和医院类型外，两个种族组具有相似的社会人口学和临床属性。在治疗后3个月，两组都经历了身体健康状况的下降和前列腺癌特殊担忧的增加。这些指标的基线值在24个月的随访期内均未恢复。特别是，缺乏能量是导致身体健康状况下降的最主要因素。勃起和保持勃起的能力是前列腺癌最严重的问题。在随访期内，两组患者缺乏精力和对勃起能力的担忧各不相同。对于非裔美国人患者，这项指标有很大的时间差异，而高加索患者则报告随着时间的推移能量有所改善。结论我们的发现不仅提供了对身体健康和前列腺癌特殊关注的总体种族差异的洞察，而且还提供了在24个月随访期间这些指标的时间差异。这对不同种族的局限性前列腺癌患者的有效管理具有重要意义，值得进一步研究。癌症幸存者解决精力不足以及对勃起能力和维持勃起能力的担忧的意义可以帮助改善局限性前列腺癌幸存者的身体健康，缓解前列腺癌幸存者的前列腺特异性担忧。
Background We analyzed the racial differences in physical well-being, social/family well-being, functional well-being, emotional well-being, and prostate cancer specific concerns among men with clinically localized prostate cancer.Methods In this prospective cohort study, we recruited 121 Caucasian and 77 African American men with newly diagnosed prostate cancer. Participants completed the Functional Assessment of Cancer Therapy-Prostate (FACT-P) instrument at baseline and at 3, 6, 12 and 24 months follow-up. To determine the between and within group differences on all functional measures (physical well-being, social/family well-being, functional well-being, emotional well-being, and prostate cancer specific concerns), we used repeated measures ANOVA.Results Except for education, income and hospital type, the two racial groups had comparable socio-demographic and clinical attributes. At 3 months post-treatment, both groups experienced a decline in physical well-being and increase in prostate cancer specific concerns. Baseline values of these measures were not recovered by 24-month follow-up. In particular, lack of energy was the most prominent contributor to declining physical well-being. The ability to have and maintain an erection was the most severe prostate cancer specific concern. Lack of energy and concern regarding erection ability varied between the two groups over the follow-up period. For African American patients, there was substantial temporal variation in this item, whereas Caucasian patients reported improved energy over time.Conclusions Our findings provide an insight into not only the overall racial variation in physical well-being and prostate cancer specific concern, but also the temporal differences in these measures that can occur over a 24-month follow-up. This has important implications for effective management of localized prostate cancer patients from different racial groups and merits further research.Implications for cancer survivors Addressing the issue of lack of energy and concern regarding ability to have and maintain an erection can help improve physical well-being and alleviate prostate-specific concerns in survivors of localized prostate cancer.