Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene
Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene
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DOI：
10.1016/s0925-4773(03)00095-9
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发表时间：
2002-12-01
影响因子：
2.6
通讯作者：
Henrique, Domingos
中科院分区：
文献类型：
--
作者：
Bekman, Evguenia;Henrique, Domingos
黑腹果蝇（Drosophila melanogaster）基因刺-刺-腿（pk）在细胞间反馈回路中起作用，该回路通过调节卷曲-凌乱信号，对果蝇眼睛和表皮中平面细胞极性的建立起核心作用。本研究鉴定了3个小鼠刺相关基因（dyxin， testn和prickle），并描述了它们在小鼠胚胎发生过程中的表达模式（E7.5-E15.5）。我们报道了这三个基因在发育中的小鼠大脑的限制区域表达：dyxin在神经管的最腹侧区域和中脑和斜脑室层的一些局部区域，刺在脑桥区域，斜脑室腹外侧部分和脊髓的运动神经元，睾丸在脊髓和视网膜的分化神经元中表达。在分析的阶段中，睾酮的主要表达部位是迁移的颅神经嵴，而dyxin的表达在肌瘤细胞及其衍生物中很明显，而棘蛋白的表达则相互定位于一些硬瘤衍生物，如骨原基。刺状蛋白也表达于顶端外胚层脊和最远端的间质。(C) 2003爱思唯尔科学爱尔兰有限公司版权所有。
The Drosophila melanogaster gene prickle-spiny-legs ( pk) functions in an intercellular feedback loop that is central to the establishment of planar cell polarity in the eye and epidermis of the fly, by modulating Frizzled-Disheveled signalling. Here we identify three mouse prickle-related genes ( dyxin, testin and prickle) and describe their expression pattern during murine embryogenesis ( E7.5-E15.5). We report that the three genes are expressed in restricted areas of the developing mouse brain: dyxin in the most ventral region of the neural tube and in some localized regions of the ventricular layer of the mesencephalon and rhombencephalon, prickle in the pons region, ventrolateral part of rhombencephalon and motoneurons in the spinal cord, and testin in differentiating neurons of the spinal cord and retina. At the stages analyzed, the main site of expression of testin is the migrating cranial neural crest, while the expression of dyxin is noticeable in myotomal cells and its derivatives, with prickle expression being reciprocally localized to some sclerotomal derivatives, like bone primordia. prickle is also expressed in the apical ectodermal ridge and the most distal mesenchyme of the forming limb buds. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.