Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails.
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails.
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DOI：
10.1016/j.stemcr.2020.11.003
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发表时间：
2021-03-09
影响因子：
5.9
通讯作者：
Mummery CL
中科院分区：
文献类型：
--
作者：
Yiangou L;Davis RP;Mummery CL
严重急性呼吸系统综合症冠状病毒2型（SARS-CoV-2）导致冠状病毒病（COVID-19）爆发，并于二零二零年成为大流行病，迄今已造成超过3，000万人感染及100万人死亡。随着科学界寻找治疗或消除病毒的疫苗和药物，这种疾病出现了意想不到的特征。除呼吸系统并发症外，心血管疾病已成为COVID-19预后不良的主要指标。因此，了解SARS-CoV-2如何损害心脏变得至关重要。人类多能干细胞（hPSC）心血管衍生物被迅速认为是解决这一问题的宝贵工具，尤其是因为病毒的主要受体之一在小鼠中不被SARS-CoV-2识别。在这里，我们概述了hPSC衍生的心血管细胞如何用于研究COVID-19，以及它们在进一步了解心脏病理学和治疗开发方面的潜力。从这个角度来看，Mummery及其同事概述了hPSC衍生的心血管细胞如何用于研究COVID-19。他们描述了这些模型在揭示SARS-CoV-2如何感染心脏方面所提供的最新进展，并提出了如何进一步利用它们来快速推进我们对由此产生的心血管病理学的理解，以及它们在开发治疗方法中的潜在作用。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the coronavirus disease (COVID-19) outbreak that became a pandemic in 2020, causing more than 30 million infections and 1 million deaths to date. As the scientific community has looked for vaccines and drugs to treat or eliminate the virus, unexpected features of the disease have emerged. Apart from respiratory complications, cardiovascular disease has emerged as a major indicator of poor prognosis in COVID-19. It has therefore become of utmost importance to understand how SARS-CoV-2 damages the heart. Human pluripotent stem cell (hPSC) cardiovascular derivatives were rapidly recognized as an invaluable tool to address this, not least because one of the major receptors for the virus is not recognized by SARS-CoV-2 in mice. Here, we outline how hPSC-derived cardiovascular cells have been utilized to study COVID-19, and their potential for further understanding the cardiac pathology and in therapeutic development. In this perspective, Mummery and colleagues outline how hPSC-derived cardiovascular cells can be used to investigate COVID-19. They describe the recent advances these models have provided in uncovering how SARS-CoV-2 infects the heart and propose how they could be further utilized to rapidly advance our understanding of the resulting cardiovascular pathology, as well as their potential role in developing therapies.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
心肌梗塞会增加大鼠和人类 ACE2 的表达
影响因子：
39.3
作者：
Burrell, LM;Risvanis, J;Johnston, CI
通讯作者：
Johnston, CI
影响因子：
5.6
作者：
Clyne, Alisa Morss;Zhu, Han;Edelman, Elazer R.
通讯作者：
Edelman, Elazer R.