THERMOSENSITIVE SINGLE-UNIT ACTIVITY OF INVITRO HYPOTHALAMIC SLICES
THERMOSENSITIVE SINGLE-UNIT ACTIVITY OF INVITRO HYPOTHALAMIC SLICES
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DOI：
10.1152/ajpregu.1982.242.1.r77
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
BOULANT, JA
中科院分区：
文献类型：
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作者：
KELSO, SR;PERLMUTTER, MN;BOULANT, JA
在离体大鼠视前区-下丘脑前部组织切片上记录单个单位活动。139个单位的热敏性是由它们对切片温度变化的反应而引起的放电率变化来确定的。在这些神经元中，30%的神经元是热敏感的，10%是冷敏感的，60%是温度不敏感的。这些比例与全动物研究中获得的结果相似，表明这是一种可行的制剂。下丘脑神经元的温度敏感性明显不依赖于外周传入信息。所有装置在37 °时的发射率都很低（< 10 imp/s）。83%的温敏单位的温度敏感性大于37 ℃。C.传入神经元的温度敏感性明显决定了其放电频率的高低和范围。冷敏感单位在37 ℃以上也显示出最大的热敏性。如果冷敏感神经元从附近的温敏感神经元接收抑制性突触输入，这将是预期的。
Single-unit activity was recorded in vitro from tissue slices of rat preoptic area-anterior hypothalamus. The thermosensitivity of 139 units was determined by their changes in firing rate in response to changes in slice temperature. Of these neurons, 30% were warm sensitive, 10% were cold sensitive and 60% were temperature insensitive. These proportions are similar to results obtained in whole-animal studies, indicating that this is a viable preparation. Hypothalamic neuronal thermosensitivity apparently is not dependent on peripheral afferent input. All units had low firing rates (< 10 imp/s) at 37.degree. C, and 83% of the warm-sensitive units were most thermosensitive > 37.degree. C. Afferent input evidently determines the level of firing rate and range of thermosensitivity of warm-sensitive neurons. The cold-sensitive units also displayed maximal thermosensitivity above 37.degree. C, which would be expected if cold-sensitive neurons received inhibitory synaptic input from nearby warm-sensitive neurons.