The Differential Diagnostic Value of the Callosal Angle and Evans Index in Mild Cognitive Impairment and Alzheimer's Disease.
The Differential Diagnostic Value of the Callosal Angle and Evans Index in Mild Cognitive Impairment and Alzheimer's Disease.
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DOI：
10.2174/1573405616666201223150004
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发表时间：
2021
影响因子：
1.4
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Liu M;Zhang J;Zong L;Fan W;Wang B;Chen Z
胼胝体角（CA）和Evans指数（EI）被认为是使用传统MR测量方法诊断正常压力脑积水的成像生物标志物。本研究旨在评价CA和EI对轻度认知功能障碍（MCI）和阿尔茨海默病（AD）的鉴别诊断价值。从阿尔茨海默病神经影像学倡议（ADNI）数据库中选择了502名受试者，其中包括168名正常对照（NC），233名MCI和101名AD患者。将结构MR图像与多平面重建交互应用，以测量CA和EI。CA在NC组、MCI组和AD组间无显著性差异（H值= 3.848，P值= 0.146），EI在MCI组和AD组均高于NC组（P值分别为0.000和0.001）。MCI组70-75岁各年龄组的EI（0.29±0.04）显著高于NC组（0.27±0.03）。ROC曲线显示70-75岁年龄组NC-MCI的曲线下面积为0.704±0.045。相关分析显示，MCI患者的EI与MMSE评分呈显著负相关（r =-0.131，P = 0.046）。EI可作为70-75岁MCI患者的筛查性影像学标志物，对AD的诊断鉴别价值有限。CA对MCI和AD无诊断价值。
Callosal Angle (CA) and Evans Index (EI) are considered as imaging biomarkers to diagnose normal-pressure hydrocephalus using traditional MR measurement methods. The current study aimed to evaluate the differential diagnostic value of CA and EI in Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Five-hundred and two subjects were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, which included 168 Normal Controls (NC), 233 MCI and 101 AD patients. The structural MR images were interactively applied with multiplanar reconstruction to measure the CA and EI. CA presented no significant difference among NC, MCI and AD groups (H value = 3.848, P value = 0.146), and EI demonstrated higher value in MCI and AD groups than that in NC groups (P = 0.000 and 0.001, respectively). MCI group had significant larger EI (0.29±0.04) than (0.27±0.03) NC group in 70-75 years old sub-groups. ROC showed that the area under the curve was 0.704±0.045 for NC-MCI in 70-75 years old groups. The correlation analysis indicated that EI was significantly negatively related to MMSE scores of MCI patients (r = -0.131, P = 0.046). EI might serve as a screening imaging biomarker for MCI in 70-75 years old patients, and show limited differential value for the diagnosis of AD. CA could present no diagnostic value for MCI and AD in the current study.