Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
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DOI：
10.1186/2045-9912-1-11
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发表时间：
2011-06-07
影响因子：
2.9
通讯作者：
Nakao A
中科院分区：
文献类型：
--
作者：
Kang KM;Kang YN;Choi IB;Gu Y;Kawamura T;Toyoda Y;Nakao A
接受放射治疗的癌症患者经常会感到疲劳和生活质量（QOL）受损。据信，放射治疗的许多副作用都与放射治疗期间产生的活性氧引起的氧化应激和炎症增加有关。氢气可以作为治疗性医用气体，具有抗氧化特性，并减少组织中的炎症。本研究检查了氢治疗（以补充氢的水的形式）是否改善了接受放射治疗的患者的生活质量。本研究采用随机、安慰剂对照的方法，对49例接受放射治疗的恶性肝肿瘤患者饮用富氢水的效果进行了评价。通过将金属镁棒放入饮用水（最终氢浓度; 0.55~0.65 mM）中来制备富氢水。使用欧洲癌症研究和治疗组织的QLQ-C30量表的韩国版本来评估总体健康状况和QOL。评估外周血中活性氧化代谢产物衍生物的浓度和生物抗氧化能力。6周的富氢水消耗减少了血液中的活性氧代谢产物，并保持了血液氧化电位。与接受安慰剂水治疗的患者相比，接受富氢水治疗的患者在放疗期间的QOL评分显著改善。两组间肿瘤对放疗的反应无差异。每日饮用富氢水是一种潜在的新型治疗策略，可改善辐射暴露后的生活质量。富氢水的消耗减少了对辐射诱导的氧化应激的生物反应，而不损害抗肿瘤作用。
Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.