Occupational risks for idiopathic pulmonary fibrosis mortality in the United States
Occupational risks for idiopathic pulmonary fibrosis mortality in the United States
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DOI：
10.1179/oeh.2008.14.2.117
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发表时间：
2008-04-01
影响因子：
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通讯作者：
Wassell, James T.
中科院分区：
文献类型：
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作者：
Pinheiro, Germania A.;Antao, Vinicius C.;Wassell, James T.
金属和木尘暴露已被确定为特发性肺纤维化(IPF)的可能职业危险因素。我们使用ICD-10代码J84.1-“其他间质性肺疾病伴纤维化”来分析死亡率数据，得出1999-2003年的年龄调整死亡率，并通过使用匹配的病例对照方法计算比例死亡率比(PMR)和死亡率优势比(MORS)来评估1999年的职业风险。我们确定了84,010例IPF死亡病例，年龄调整死亡率为75.7例/百万人。男性、白人和85岁及以上人群的死亡率最高。被确认为IPF危险因素的潜在职业暴露的三个行业类别：“木结构建筑和活动房屋”(PMR=4.5，95%可信区间(CI)1.2-11.6，MOR=5.3，95%可信区间1.2-23.8)，“金属采矿”(PMR=2.4，95%CI 1.3-4.0，MOR=2.2，95%CI 1.1-4.4)，以及“金属制品”(PMR=1.9，95%CI为1.1~3.1，MOR=1.7，95%CI为1.0~3.1)。这些行业类别的工人可能受益于毒理学研究和对这种疾病的改进监测。
Metal and wood dust exposures have been identified as possible occupational risk factors for idiopathic pulmonary fibrosis (IPF). We analyzed mortality data using ICD-10 code J84.1-"Other interstitial pulmonary diseases with fibrosis," derived age-adjusted mortality rates for 1999-2003, and assessed occupational risks for 1999, by calculating proportionate mortality ratios (PMRs) and mortality odds ratios (MORs) using a matched case-control approach. We identified 84,010 IPF deaths, with an age-adjusted mortality rate of 75.7 deaths/million. Mortality rates were highest among males, whites, and those aged 85 and older. Three industry categories with potential occupational exposures recognized as risk factors for IPF were identified: "Wood buildings and mobile homes" (PMR = 4.5, 95% confidence interval (CI) 1.2-11.6 and MOR = 5.3, 95% CI 1.2-23.8), "Metal mining" (PMR = 2.4, 95% CI 1.3-4.0 and MOR = 2.2, 95% CI 1.1-4.4), and "Fabricated structural metal products" (PMR = 1.9, 95% CI 1.1-3.1 and MOR = 1.7, 95% CI 1.0-3.1). Workers in these industry categories may benefit from toxicological studies and improved surveillance for this disease.