Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese
Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese
复制标题
胰高血糖素基因多态性改变吸烟和体力活动对汉族2型糖尿病风险的影响
DOI：
10.1016/j.gene.2013.09.121
复制
发表时间：
2014-01-25
期刊：
影响因子：
3.5
通讯作者：
Hu, Dongsheng
中科院分区：
文献类型：
--
作者：
Li, Linlin;Gao, Kaiping;Hu, Dongsheng
很少有全基因组关联研究考虑了多种遗传变异与疾病相关的环境因素之间的相互作用。在中国汉族人群中进行了一项病例对照研究，研究胰高血糖素基因（GCG）多态性与吸烟、饮酒和体力活动之间的相互作用，以及与2型糖尿病（T2 DM）风险的关联。通过二元多元逻辑回归分析了9619名参与者的GCG rs 12104705多态性以及与环境变量的相互作用。吸烟与C-C单倍型rs 12104705相关（OR = 1.174，95%CI = 1.013 ~ 1361）。C-C基因型的中、高体力活动与2型糖尿病的危险性相关（OR = 0.251，95%CI = 0.206 ~ 0.220）。然而，饮酒和基因型的交互作用与T2 DM的风险无关。GCG基因rs 12104705多态性可能与吸烟和体力活动相互作用，改变T2 DM的发病风险。(C)2013爱思唯尔有限公司版权所有。
Few genome-wide association studies have considered interactions between multiple genetic variants and environmental factors associated with disease. The interaction was examined between a glucagon gene (GCG) polymorphism and smoking, alcohol consumption and physical activity and the association with risk of type 2 diabetes mellitus (T2DM) in a case-control study of Chinese Han subjects. The rs12104705 polymorphism of GCG and interactions with environmental variables were analyzed for 9619 participants by binary multiple logistic regression. Smoking with the C-C haplotype of rs12104705 was associated with increased risk of T2DM (OR = 1.174, 95% Cl = 1.013-1361). Moderate and high physical activity with the C-C genotype was associated with decreased risk of T2DM as compared with low physical activity with the genotype (OR = 0.251, 95% CI = 0.206-0306 and OR = 0.190, 95% CI = 0.164-0.220). However, the interaction of drinking and genotype was not associated with risk of T2DM. Genetic polymorphism in rs12104705 of GCG may interact with smoking and physical activity to modify the risk of T2DM. (C) 2013 Elsevier B.V. All rights reserved.