A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I Seeds: A Feasibility and Safety Study in Healthy Beagle Dog
A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I Seeds: A Feasibility and Safety Study in Healthy Beagle Dog
复制标题
一种装载 I-125 粒子的新型自膨胀放射性气道支架：健康比格犬的可行性和安全性研究
DOI：
10.1007/s00270-017-1639-8
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发表时间：
2017-07-01
影响因子：
2.9
通讯作者：
Teng, Gao-Jun
中科院分区：
文献类型：
--
作者：
Wang, Yong;Guo, Jin-He;Teng, Gao-Jun
目的气管内支架置入术是治疗恶性呼吸道阻塞的有效方法。然而，支架术后肿瘤向内生长和/或过度生长导致的再狭窄是很常见的。材料与方法48只健康比格犬随机分为4组(A组：0.3MCI；B组：0.6MCI；C组：0.9MCI；对照组：0MCI)。用各向同性点源近似计算了估算的辐射剂量。支架置入后2、4、8、16周分别对支架置入后的气管段及邻近器官组织进行放射学随访和组织病理学检查。结果所有支架均成功置入Beagle犬的靶段，无手术相关并发症。4组大鼠气管狭窄程度均逐渐加重，与I-125籽粒放射性无关(p>；0.05)。气管损伤评分随着放射性粒子剂量的增加而增加，8周达到峰值，16周略有回落。光镜下邻近组织未见病理组织学改变，而电子显微镜下可见轻度、可逆的超微结构改变。结论本研究证实了这种新型I-125种子自扩张式支架植入健康比格犬体内是安全可行的。
Purpose Airway stent placement is an effective treatment for the immediate palliation of malignant airway obstruction. However, restenosis caused by tumor ingrowth and/or overgrowth after stenting is common. The purpose of this study was to investigate the feasibility and safety of a novel self-expandable stent loaded with I-125 seeds in healthy beagle dog.Materials and Methods Under fluoroscopic guidance, forty-eight self-expandable airway stents loaded with I-125 seeds were perorally placed in the main trachea of 48 healthy beagle dogs, who were randomly divided into four groups (Group A: 0.3 mCi; Group B: 0.6 mCi; Group C: 0.9 mCi; Control group: 0 mCi). The estimated radiation dose was calculated using the isotropic point source approximation. Radiological follow-up examinations and histopathological examinations of stented tracheal segments and their adjacent organs and tissues were performed at 2, 4, 8, and 16 weeks following the stenting.Results All stents were successfully deployed in the targeted tracheal segment in the beagle dogs without procedure-related complications. Tracheal stenosis became severe gradually in all the four groups, which was not associated with the radioactivity of I-125 seeds (p > 0.05). The tracheal injury scores increased along with the higher dose of radioactive seeds which reached peak at 8 weeks and then turned back slightly at 16 weeks. The adjacent tissue did not show pathohistological changes under microscope, while mild and reversible ultrastructure changes were showed under electronic microscope.Conclusions This study demonstrates that it is feasible and safe to insert this novel self-expandable airway stent loaded with I-125 seeds in healthy beagle dog.